Protein Info for DDA3937_RS13055 in Dickeya dadantii 3937

Annotation: thiamine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01636: APH
  • amino acids 32 to 238 (207 residues), 59.6 bits, E=4.2e-20
• PF01633: Choline_kinase
  • amino acids 62 to 222 (161 residues), 25.5 bits, E=9.1e-10

Best Hits

KEGG orthology group: K07251, thiamine kinase [EC: 2.7.1.89] (inferred from 100% identity to ddd:Dda3937_02257)

Predicted SEED Role

"Thiamine kinase (EC 2.7.1.89) @ Adenosylcobinamide kinase (EC 2.7.1.156)" (EC 2.7.1.156, EC 2.7.1.89)

MetaCyc Pathways

• thiamine diphosphate salvage I (2/2 steps found)
• adenosylcobinamide-GDP salvage from cobinamide I (4/5 steps found)
• superpathway of adenosylcobalamin salvage from cobinamide I (4/8 steps found)

KEGG Metabolic Maps

• Porphyrin and chlorophyll metabolism
• Thiamine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.1.156 or 2.7.1.89

Sequence Analysis Tools

See E0SH02 at UniProt or InterPro

Protein Sequence (287 amino acids)

>DDA3937_RS13055 thiamine kinase (Dickeya dadantii 3937)
MVRSANSEALNALLQQALPAVATAGFYLQPVSGLSHQSWRIHSPAGLWLARGETPQGRQL
GTSRQREFHVLRQLAGQSLAPHPVCWHDGWLLVEWLAGEPADARQFAQSLAEGRLAAMLA
RLHHQPRYGYPLPLKRLMAQHWQHMDPARRSPRLRRAYQQVVDKPLPTPLLIAPLHLDVH
PGNLLCTEAGWRLIDWEYAADGDIGLELALLFRACELDDARQQDFLQAYCRHWRHLRPAS
LRRQTARWQYWVDYLVLMWFEVRWRQSGETYYRQTADALRRVAGWRG