Protein Info for DDA3937_RS11255 in Dickeya dadantii 3937
Annotation: aminodeoxychorismate synthase component 1
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 71% identical to PABB_KLEAE: Aminodeoxychorismate synthase component 1 (pabB) from Klebsiella aerogenes
KEGG orthology group: K01665, para-aminobenzoate synthetase component I [EC: 2.6.1.85] (inferred from 100% identity to ddd:Dda3937_03719)MetaCyc: 68% identical to aminodeoxychorismate synthase subunit 1 (Escherichia coli K-12 substr. MG1655)
Aminodeoxychorismate synthase. [EC: 2.6.1.85]
Predicted SEED Role
"Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 2.6.1.85)
MetaCyc Pathways
- superpathway of chorismate metabolism (54/59 steps found)
- superpathway of tetrahydrofolate biosynthesis and salvage (11/12 steps found)
- superpathway of tetrahydrofolate biosynthesis (9/10 steps found)
- ammonia assimilation cycle III (3/3 steps found)
- 4-aminobenzoate biosynthesis I (2/2 steps found)
- L-glutamate biosynthesis I (2/2 steps found)
- L-glutamine degradation I (1/1 steps found)
- L-asparagine biosynthesis III (tRNA-dependent) (3/4 steps found)
- glutaminyl-tRNAgln biosynthesis via transamidation (3/4 steps found)
- L-glutamate and L-glutamine biosynthesis (5/7 steps found)
- L-citrulline biosynthesis (5/8 steps found)
- superpathway of L-citrulline metabolism (7/12 steps found)
- superpathway of candicidin biosynthesis (4/11 steps found)
- chloramphenicol biosynthesis (1/9 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 2.6.1.85
Use Curated BLAST to search for 2.6.1.85
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E0SDA7 at UniProt or InterPro
Protein Sequence (456 amino acids)
>DDA3937_RS11255 aminodeoxychorismate synthase component 1 (Dickeya dadantii 3937) MPTPIVYHALPYQPDVLLRLFSSLSRQPWAMLLHSGFADHPHNRFDILVAEPRLTLQTVG ELTTIQHGDTLQTSTEDPFHLLQQQLDALALDVAPHPDYPFQGGALGLFGYDLGRRVEQL PAIAERDIDLPDMAVGIYDWALIADHHQRRLTLIAHGDINARLAWLENLTPAEPGAFCLT SAWQANMSREQYGEKFHRIQDYLRAGDCYQVNLAQRFQAGYQGDEWQAFLTLSASNRAPF SAFLRLPHSAVLSISPERFLWLHDNHIQTRPIKGTLPRLPDADADARQAQRLAASEKDRA ENLMIVDLLRNDIGRVAVPGSVRVPELFVVEPFPAVHHLVSTIEARLPAQQQATDLLRAC FPGGSITGAPKVRAMEIIEELEPHRRNAYCGSIGYLSVCGTMDTNITIRTLIAADGTLSC WAGGGIVADSEEQAEYQETFDKIGRILPLLTVSTTD