Protein Info for DDA3937_RS10470 in Dickeya dadantii 3937
Annotation: bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 70% identical to TRPC_SALTY: Tryptophan biosynthesis protein TrpCF (trpC) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG orthology group: K13498, indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase [EC: 4.1.1.48 5.3.1.24] (inferred from 100% identity to ddd:Dda3937_00574)MetaCyc: 70% identical to fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase (Escherichia coli K-12 substr. MG1655)
Phosphoribosylanthranilate isomerase. [EC: 5.3.1.24]; Indole-3-glycerol-phosphate synthase. [EC: 5.3.1.24, 4.1.1.48]
Predicted SEED Role
"Indole-3-glycerol phosphate synthase (EC 4.1.1.48) / Phosphoribosylanthranilate isomerase (EC 5.3.1.24)" in subsystem Tryptophan synthesis or Auxin biosynthesis (EC 4.1.1.48, EC 5.3.1.24)
MetaCyc Pathways
- superpathway of chorismate metabolism (54/59 steps found)
- superpathway of aromatic amino acid biosynthesis (18/18 steps found)
- superpathway of L-tryptophan biosynthesis (13/13 steps found)
- L-tryptophan biosynthesis (6/6 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Phenylalanine, tyrosine and tryptophan biosynthesis
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.1.1.48 or 5.3.1.24
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E0SBW3 at UniProt or InterPro
Protein Sequence (461 amino acids)
>DDA3937_RS10470 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF (Dickeya dadantii 3937) MQETVLTKIVRDKAQWIAERQQRQPLDSFQSQVTPSSRHFYQSLKQASPAFILECKKASP SKGLIRADFDPVAIARVYQDYASAISVLTDEKYFQGDFAFLTQVSAAVAQPVLCKDFIID PYQIYLARYYQADAILLMLSVLDDAQYRQLAQVAHSLNMGILTEVSNEAELERAIALEAR VVGINNRDLRDLSIDLNRTRTLAPRLPAGVTVISESGISRHAHIQELSQYANGFLIGSSL MEEHDLTLAVRRVILGENKVCGLTRPDDATAAFQAGAVYGGLIFVADSPRYVTTSQARAV MAGAPLRYVGVFRDAPLADIVATASSLQLAAVQLHGHEDQAAIAALREQLPATCQIWKAH SVGDTLPPLTLAQVDRVLLDNGKGGSGQSFDWSLLQGQSLQQVLLAGGLGPSNVAQAATL GVAGLDFNSGVESQPGIKDPQKIAAVFRTLRTAQPCRTSHE