Protein Info for DDA3937_RS09670 in Dickeya dadantii 3937

Annotation: 3-phosphoserine/phosphohydroxythreonine transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 90% identical to SERC_PECCP: Phosphoserine aminotransferase (serC) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)

KEGG orthology group: K00831, phosphoserine aminotransferase [EC: 2.6.1.52] (inferred from 100% identity to ddd:Dda3937_04327)

MetaCyc: 78% identical to phosphoserine/phosphohydroxythreonine aminotransferase (Escherichia coli K-12 substr. MG1655)
Phosphoserine transaminase. [EC: 2.6.1.52]; 2.6.1.52 [EC: 2.6.1.52]; Succinyldiaminopimelate transaminase. [EC: 2.6.1.52, 2.6.1.17]

Predicted SEED Role

"Phosphoserine aminotransferase (EC 2.6.1.52)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 2.6.1.52)

MetaCyc Pathways

aspartate superpathway (24/25 steps found)
superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (18/18 steps found)
superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (12/12 steps found)
L-lysine biosynthesis I (9/9 steps found)
superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
pyridoxal 5'-phosphate biosynthesis I (7/7 steps found)
superpathway of L-serine and glycine biosynthesis I (4/4 steps found)
L-serine biosynthesis I (3/3 steps found)
L-cysteine biosynthesis IX (Trichomonas vaginalis) (2/3 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.17, 2.6.1.52

Use Curated BLAST to search for 2.6.1.17 or 2.6.1.52

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SMZ2 at UniProt or InterPro

Protein Sequence (361 amino acids)

>DDA3937_RS09670 3-phosphoserine/phosphohydroxythreonine transaminase (Dickeya dadantii 3937)
MTQVFNFSAGPAMLPVEVLRRAEQELCNWHGLGTSVMEISHRSKEFMQVAGESEQDLRDL
LKIPSNYKVLFCHGGARAQFAAVPLNLLGDSTKADYIDGGYWAHSAVKEAEKYLTPNVID
VKTRVDGLRGVQPMREWALSDDAAYVHYCPNETIDGLAIEETPDFGDKIVVADYSSSILS
RPLDVSRYGVIYAGAQKNVGPAGLTLVIVREDLLGKARRELPSILDYKTLADNDSMFNTP
PTFAWYLSGMVFKWLKEQGGLLEMEKRNQAKADLLYAAIDGSDFYRNDVVRANRSRMNVP
FQLADAALDPVFLQEAQAAGLHALKGHRVVGGMRASIYNAMPLDGVKALTEFMVDFERRH
G