Protein Info for DDA3937_RS08100 in Dickeya dadantii 3937

Annotation: triphosphoribosyl-dephospho-CoA synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 285 transmembrane" amino acids 108 to 131 (24 residues), see Phobius details TIGR03132: triphosphoribosyl-dephospho-CoA synthase MdcB" amino acids 13 to 278 (266 residues), 305.5 bits, see alignment E=1.8e-95 PF01874: CitG" amino acids 18 to 275 (258 residues), 223.3 bits, see alignment E=2.5e-70

Best Hits

Swiss-Prot: 73% identical to MDCB_KLEPN: 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (mdcB) from Klebsiella pneumoniae

KEGG orthology group: K13930, triphosphoribosyl-dephospho-CoA synthase [EC: 2.7.8.25] (inferred from 90% identity to ddc:Dd586_2523)

MetaCyc: 73% identical to 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (Klebsiella pneumoniae)
2.7.8.25-RXN [EC: 2.4.2.52]

Predicted SEED Role

"Triphosphoribosyl-dephospho-CoA synthetase (EC 2.7.8.25)" in subsystem Malonate decarboxylase (EC 2.7.8.25)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.52, 2.7.8.25

Use Curated BLAST to search for 2.4.2.52 or 2.7.8.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SJB2 at UniProt or InterPro

Protein Sequence (285 amino acids)

>DDA3937_RS08100 triphosphoribosyl-dephospho-CoA synthase (Dickeya dadantii 3937)
MKPQRQSDAHGYAQWLAGAATRCLIEEARLSPKPGLVDSRGSGAHQDLTLALMERSAHSL
TATFHALALQSWQRPADAALRQLVGRVGREGEQRMLLATDGVNTHRGAIWALGLLVSAAA
MLGGVGTAQAIADTAAHLARLPDNAAPTVFSNGRRATQRYQVPGAREEAQQGFPHITRLA
LPQLLRSRRQGAGEDDARLDALMSIMTSLSDTCVLSRAGLDGLAAMQRGARAVLAAGGVS
RPAGRQALEQLDTRMLTLNASPGGAADLLAATLLLDGIAQPSLYD