Protein Info for DDA3937_RS07375 in Dickeya dadantii 3937

Annotation: beta-galactosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1037 PF02837: Glyco_hydro_2_N" amino acids 61 to 226 (166 residues), 221.4 bits, see alignment E=1.9e-69 PF00703: Glyco_hydro_2" amino acids 228 to 343 (116 residues), 46.2 bits, see alignment E=1.8e-15 PF02836: Glyco_hydro_2_C" amino acids 345 to 637 (293 residues), 383.8 bits, see alignment E=1.3e-118 PF16353: LacZ_4" amino acids 648 to 736 (89 residues), 72.9 bits, see alignment E=5.3e-24 PF02929: Bgal_small_N" amino acids 767 to 1034 (268 residues), 196.3 bits, see alignment E=1.9e-61

Best Hits

Swiss-Prot: 64% identical to BGAL1_KLEP7: Beta-galactosidase 1 (lacZ1) from Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578)

KEGG orthology group: K01190, beta-galactosidase [EC: 3.2.1.23] (inferred from 100% identity to ddd:Dda3937_00746)

Predicted SEED Role

"Beta-galactosidase (EC 3.2.1.23)" in subsystem Galactosylceramide and Sulfatide metabolism or Lactose and Galactose Uptake and Utilization or Lactose utilization (EC 3.2.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.2.1.23

Use Curated BLAST to search for 3.2.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SHJ2 at UniProt or InterPro

Protein Sequence (1037 amino acids)

>DDA3937_RS07375 beta-galactosidase (Dickeya dadantii 3937)
MSTASAYAPLSDISLADILARRDWENPACPHVRRLDAHPPFSSWRGLDAARDDQPSERRQ
QLNGAWTFSYFPRPEAVPEQWLTQDLTDADAITVPSNWQLAGYDAPIYTNIKYPIPVNPP
FVPQDNPTGCYSLTFSVNADWLTQGQTRIVFDGVNSAFHLWCNGKWVGYSQDSRLPAEFD
LTPCLQPGENRLAVMVLRWSDGTYLEDQDMWRMSGIYRDVYLLHKPAVHLRDVQLTTPLR
HSYTQGTLCVTAQANLPEDQAQAWRLNVQLWRDGQLVGERRAPFGTPAIDERGAYHDRVN
LQIEVERPALWSAEEPNLYRAVVALEYADGTLAEAEAYDVGFREVAIRNGLLLLNGQPLL
IRGVNRHEHHPQRGQAIDEATMRQDILLMKQHNFNAVRCSHYPNHPLWYRLCDYYGLYVV
DEANIETHGMQPMSRLSDDPRWLPAYAERVTRMVQRDRNHPCIIIWSLGNESGYGPTHSA
LYQWVKQQDPSRPVQYEGGGANTPATDILCPMYARVDQDQPFPAVPKWSIKKWIGLPGEN
RPLILCEYAHAMGNSFGGFDRYWQAFRQYPRLQGGFVWDWVDQALLREQDGKTHWAYGGD
FGDKPNDRQFCLNGLVFPDRTPHPALYEAQRAQQFFQFTRHESAPLTLTVTSEYLFRHSD
NEELRWRIMQDDVPLASGTVPLDIAPQGCQTLTLLDQLPAPQHHADMWLTVEVVQPHATD
WSPAEHRCAWDQWPLPMPLAHSAPHRNDGACPTLTRDDDHFDIIHDQQRWSFDRRSGLLT
QWWRDGQPQLLSPLQDNLTRAPLDNDIGISEVDRIDPNAWVERWKLAGLYQYQTDCRQIR
ADTLSDSVLITTEHVGHYQQQTLFISRKQWRIDAQGVLTVSVEVDVARHLPPLARIGLYG
QLAAVNPQVSWLGLGPHENYPDRRLAALHGRWQQPLEAMHTPYIFPSENGLRCHTRELRY
GDWLIEGDFHFGISRYSLQQLMDCTHQHLLQPEPGTWLNLDGFHMGIGGDDSWSPSVAPN
FLLTAPRYRYQLQLRLQ