Protein Info for DDA3937_RS06940 in Dickeya dadantii 3937

Annotation: AMP nucleosidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 485 TIGR01717: AMP nucleosidase" amino acids 12 to 485 (474 residues), 765.2 bits, see alignment E=1.4e-234 PF10423: AMNp_N" amino acids 13 to 166 (154 residues), 174.9 bits, see alignment E=9.8e-56 PF01048: PNP_UDP_1" amino acids 270 to 432 (163 residues), 74.8 bits, see alignment E=7.2e-25

Best Hits

Swiss-Prot: 78% identical to AMN_ECOLI: AMP nucleosidase (amn) from Escherichia coli (strain K12)

KEGG orthology group: K01241, AMP nucleosidase [EC: 3.2.2.4] (inferred from 100% identity to ddd:Dda3937_00834)

MetaCyc: 78% identical to AMP nucleosidase (Escherichia coli K-12 substr. MG1655)
AMP nucleosidase. [EC: 3.2.2.4]

Predicted SEED Role

"AMP nucleosidase (EC 3.2.2.4)" in subsystem Purine conversions (EC 3.2.2.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.2.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SGK9 at UniProt or InterPro

Protein Sequence (485 amino acids)

>DDA3937_RS06940 AMP nucleosidase (Dickeya dadantii 3937)
MSYAPGAGLSASEALDQLEALYDRSVKALRTAIGDFITHGTLPDAAERANGLFVYPELRI
SWDGQSQKHNKTRAYGRLTHSGSYRTTVTRPQLFRHYLAEQLAILENDYSATIEVAPSDK
EIPYPYVIDGANLGLERSMSAVLAQHFPTPSLALIGDETADGLLQTLDHFPLSHFDALRT
DFSLARLRHYTGTRAEHFQPFVLFTNYTRYVDEFVRWACDQIADPSSPYQALACAGGALI
TADTDNPQQAVSDLAWKNHQMPAYHLISREGRGITLVNIGVGPSNAKTICDHLAVLRPHA
WLMIGHCGGLRESQTIGDYVLAHAYLRDDHVLDSVLPPDIPIPSIAEVQRALYDATKQVS
GMPGEEVKQRLRTGTVVTTDDRNWELRYSASALRFNLSRAVAVDMESATIAAQGYRFRVP
YGTLLCVSDKPLHGEIKLPGQANRFYEGAISEHLQIGIRTVDLLRAEAEHLHSRKLRTFN
EPPFR