Protein Info for DDA3937_RS06585 in Dickeya dadantii 3937

Annotation: TolC family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 419 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF02321: OEP" amino acids 30 to 214 (185 residues), 38.9 bits, see alignment E=4.3e-14 amino acids 237 to 412 (176 residues), 90.2 bits, see alignment E=7.8e-30

Best Hits

KEGG orthology group: None (inferred from 100% identity to ddd:Dda3937_03992)

Predicted SEED Role

"Heavy metal RND efflux outer membrane protein, CzcC family" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SFQ7 at UniProt or InterPro

Protein Sequence (419 amino acids)

>DDA3937_RS06585 TolC family protein (Dickeya dadantii 3937)
MLTRTLRAPRAWLAMLLWLPAASFAAALDLDGALQAAEQYSADLSANQHRMNALQNMADS
ATQLPDPQLKYGIENVPLGGNNNQRLTREGMTMQRVGIMQTYVSATKRERKAQTILAEAD
TVRGNSETLRAQLQRDTAQAWLELALSRQILQEVNALVQESQRQISVQKAGVAAGGESTR
VLDARLTLSAMQDRLADATRDASIAQTRLTRLTGVADVTTQGPLPRFERLPADPAVLYAA
IADHPEIAQAEQETRLAQARAAQSAVAAIPDIGVEVYYGRRGNNFDDMAGVEISMDLPLF
QSRRQDKDHAADVARSMEARDRVALAQREHRAQLDTLLAQYQAAQSRWHRQNDEVLPLQQ
QRIRLLQSQYQSGGSDLAGVLEARRALLDSRIAAQNAARDMAALWAALRYLTPQGTAAK