Protein Info for DDA3937_RS06460 in Dickeya dadantii 3937
Annotation: 2-oxoglutarate dehydrogenase E1 component
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 87% identical to ODO1_ECOL6: 2-oxoglutarate dehydrogenase E1 component (sucA) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
KEGG orthology group: K00164, 2-oxoglutarate dehydrogenase E1 component [EC: 1.2.4.2] (inferred from 97% identity to dze:Dd1591_2914)MetaCyc: 87% identical to subunit of E1(0) component of 2-oxoglutarate dehydrogenase (Escherichia coli K-12 substr. MG1655)
Oxoglutarate dehydrogenase (succinyl-transferring). [EC: 1.2.1.105, 1.2.4.2]
Predicted SEED Role
"2-oxoglutarate dehydrogenase E1 component (EC 1.2.4.2)" in subsystem TCA Cycle (EC 1.2.4.2)
MetaCyc Pathways
- superpathway of glycolysis, pyruvate dehydrogenase, TCA, and glyoxylate bypass (25/26 steps found)
- superpathway of glyoxylate bypass and TCA (11/12 steps found)
- superpathway of cytosolic glycolysis (plants), pyruvate dehydrogenase and TCA cycle (18/22 steps found)
- TCA cycle I (prokaryotic) (9/10 steps found)
- 2-oxoglutarate decarboxylation to succinyl-CoA (3/3 steps found)
- TCA cycle III (animals) (8/10 steps found)
- TCA cycle VIII (Chlamydia) (5/6 steps found)
- TCA cycle II (plants and fungi) (7/9 steps found)
- L-lysine degradation XI (1/5 steps found)
- L-lysine degradation II (L-pipecolate pathway) (2/9 steps found)
- L-tryptophan degradation III (eukaryotic) (3/15 steps found)
- superpathway of L-lysine degradation (12/43 steps found)
KEGG Metabolic Maps
- Biosynthesis of alkaloids derived from histidine and purine
- Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
- Biosynthesis of alkaloids derived from shikimate pathway
- Biosynthesis of alkaloids derived from terpenoid and polyketide
- Biosynthesis of phenylpropanoids
- Biosynthesis of plant hormones
- Biosynthesis of terpenoids and steroids
- Citrate cycle (TCA cycle)
- Lysine degradation
- Tryptophan metabolism
Isozymes
No predicted isozymesUse Curated BLAST to search for 1.2.1.105 or 1.2.4.2
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E0SEZ4 at UniProt or InterPro
Protein Sequence (935 amino acids)
>DDA3937_RS06460 2-oxoglutarate dehydrogenase E1 component (Dickeya dadantii 3937) MQNGAMKAWLDSSYLAGANQSYIEQLYEDFLTDPDSIDHSWRSIFQQLPTTGVKPDQLHS KTRDYFRRLAKDASRYTSSITDPDSDAKQVKVLQLINAFRFRGHQHANLDPLGLWKQEHV PDLDLAYHNLTDDDLKESFNVGSFAIGKETMPLGELYAALKQTYCGPIGAEYMHITNTEE KRWIQQRIESVVGQASFTAEERKRFLKELTAAEGLERYLGAKFPGAKRFSLEGGDALIPM LKEIIRHAGKNGTREVVMGMAHRGRLNVLVNVMGKKPQDLFDEFSGKHKDHLGTGDVKYH QGFSSDMETEGGKVHLALAFNPSHLEIVSPVVIGSVRARIDRLDNPSSSLVLPITIHGDA AIAGQGVVQETLNMSKARGYEVGGTIRIVINNQIGFTTSNPRDARSTEYCTDIGKMVQAP IFHVNADDPEAVAFVTRLALDFRNTFQRDVFIDLVCYRRHGHNEADEPSATQPVMYQKIK KHPTPRKIYADRLEQQQMATLEDATELVNLYRDALDAGECVVDEWRPMDMHSFTWMSYLN HEWDEPYPHKVETKRLQELAHRISEVPEALEMQPRVAKVYSDRAEMAAGEKLFDWGGAET LAYATLVDEGIPVRLSGEDAGRGTFFHRHAVVHNQKGGSTYTPLAYVHNSQGVFNVWDSV LSEEAVLAFEYGYATAEPRTLTIWEAQFGDFANGAQVVIDQFISSGEQKWGRMCGLVMLL PHGYEGQGPEHSSARLERYLQLCAEQNMQVCIPSTPAQVYHMLRRQALRGMRRPLVVMSP KSLLRHPLATSTLDELANGQFQPAIGEIDELDPKAVKRVVLCSGKVYYDLLEQRRKNEQK DVAIVRIEQLYPFPHQAVQAALEPFAHVHDFVWCQEEPLNQGAWYCSQHHFREVIPFGAS LRYAGRPASASPAVGYMSVHQKQQQALVDDALNVN