Protein Info for DDA3937_RS06350 in Dickeya dadantii 3937

Annotation: replication initiation negative regulator SeqA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 178 PF17206: SeqA_N" amino acids 1 to 36 (36 residues), 86 bits, see alignment 7.8e-29 PF03925: SeqA" amino acids 68 to 176 (109 residues), 160 bits, see alignment E=1.9e-51

Best Hits

Swiss-Prot: 71% identical to SEQA_SALTY: Negative modulator of initiation of replication (seqA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03645, negative modulator of initiation of replication (inferred from 100% identity to ddd:Dda3937_01556)

Predicted SEED Role

"SeqA protein, negative modulator of initiation of replication"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SEX2 at UniProt or InterPro

Protein Sequence (178 amino acids)

>DDA3937_RS06350 replication initiation negative regulator SeqA (Dickeya dadantii 3937)
MKTIEVDDELYRYIASHTQHIGESASDILRRMLKFSSVQAAAATTPSPAASTTVQPAVVQ
PSRDRVRTVRELLLSDEYAEQNKAVNRFLMVLSTLYRLSPEEFSAATESLHGRTRVYFAA
DEHTLLLHGAQTKPRHIDDTPYWVITNTNTGRKRSMIEYIMLAMQFPPELTEKVCGTI