Protein Info for DDA3937_RS06235 in Dickeya dadantii 3937

Annotation: CNNM family magnesium/cobalt transport protein CorC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 289 PF00571: CBS" amino acids 66 to 121 (56 residues), 36.6 bits, see alignment E=4.6e-13 amino acids 137 to 186 (50 residues), 25.3 bits, see alignment 1.6e-09 PF03471: CorC_HlyC" amino acids 203 to 278 (76 residues), 76.4 bits, see alignment E=1.4e-25

Best Hits

Swiss-Prot: 83% identical to CORC_SALTY: Magnesium and cobalt efflux protein CorC (corC) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K06189, magnesium and cobalt transporter (inferred from 100% identity to ddd:Dda3937_02470)

Predicted SEED Role

"Magnesium and cobalt efflux protein CorC" in subsystem Copper homeostasis: copper tolerance or Phosphate metabolism

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SEV4 at UniProt or InterPro

Protein Sequence (289 amino acids)

>DDA3937_RS06235 CNNM family magnesium/cobalt transport protein CorC (Dickeya dadantii 3937)
MSDDHSPNSDTPSPKKGFFSLFLNQIFHGESKDHDDLLALIRDSEQIDPEIRDMLEGVMD
IAEQRVRDIMIPRSQMITLKHNQTLEECLDVIIESAHSRFPVISEDKDHIEGILMAKDLL
PFMRSNSEPFSMDKVLRPAVVVPESKRVDRMLNEFRSLRYHMAIVIDEFGGVSGLVTIED
ILELIVGEIEDEYDDEEDRDIRQLNRQTYTVRALTPIEDFNETFSTRFSDEEVDTIGGLV
MQSFGHLPARGETIDINGYLFKVAMADSRRIIQVHVRIPDDVPQPQLED