Protein Info for DDA3937_RS06075 in Dickeya dadantii 3937

Annotation: phosphoribosylaminoimidazolesuccinocarboxamide synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00081: phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • amino acids 3 to 235 (233 residues), 272.5 bits, E=2e-85
• PF01259: SAICAR_synt
  • amino acids 7 to 231 (225 residues), 264.3 bits, E=5.8e-83

Best Hits

Swiss-Prot: 97% identical to PUR7_PECCP: Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC) from Pectobacterium carotovorum subsp. carotovorum (strain PC1)

KEGG orthology group: K01923, phosphoribosylaminoimidazole-succinocarboxamide synthase [EC: 6.3.2.6] (inferred from 99% identity to ddc:Dd586_1118)

MetaCyc: 90% identical to phosphoribosylaminoimidazole-succinocarboxamide synthase (Escherichia coli K-12 substr. MG1655)
Phosphoribosylaminoimidazolesuccinocarboxamide synthase. [EC: 6.3.2.6]

Predicted SEED Role

"Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC 6.3.2.6)" in subsystem De Novo Purine Biosynthesis (EC 6.3.2.6)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (46/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (26/26 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• inosine-5'-phosphate biosynthesis I (6/6 steps found)
• inosine-5'-phosphate biosynthesis II (5/5 steps found)
• inosine-5'-phosphate biosynthesis III (5/6 steps found)

KEGG Metabolic Maps

• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.2.6

Sequence Analysis Tools

See E0SE30 at UniProt or InterPro

Protein Sequence (237 amino acids)

>DDA3937_RS06075 phosphoribosylaminoimidazolesuccinocarboxamide synthase (Dickeya dadantii 3937)
MQKLAELYRGKAKTVYTTEDPDLLVLEFRNDTSAGDGARIEQFDRKGMVNNKFNHFIMTK
LEEAGIPTQMVSLLSDTEVLVKKLEMVPVECVVRNRAAGSLVKRLGITEGEILNPPLFDL
FLKNDAMHDPMVNESYCKTFGWVNEENLARMKELSYKANEVLSKLFGDAGLILVDFKLEF
GLFKGEVVLGDEFSPDGSRLWDKETLNKMDKDRFRQSLGGLIEAYEEVAHRLGVKLD