Protein Info for DDA3937_RS06015 in Dickeya dadantii 3937

Annotation: HTH-type transcriptional regulator GalS

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 332 PF00356: LacI" amino acids 3 to 48 (46 residues), 71.7 bits, see alignment 7e-24 PF00532: Peripla_BP_1" amino acids 60 to 275 (216 residues), 90 bits, see alignment E=3.9e-29 PF13407: Peripla_BP_4" amino acids 62 to 278 (217 residues), 71.4 bits, see alignment E=1.8e-23 PF13377: Peripla_BP_3" amino acids 169 to 329 (161 residues), 116.7 bits, see alignment E=2.5e-37

Best Hits

Swiss-Prot: 78% identical to GALS_SALTY: HTH-type transcriptional regulator GalS (galS) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K02529, LacI family transcriptional regulator (inferred from 100% identity to ddd:Dda3937_02517)

Predicted SEED Role

"Mgl repressor and galactose ultrainduction factor GalS, HTH-type transcriptional regulator" in subsystem Lactose and Galactose Uptake and Utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SE18 at UniProt or InterPro

Protein Sequence (332 amino acids)

>DDA3937_RS06015 HTH-type transcriptional regulator GalS (Dickeya dadantii 3937)
MITIRDVARQAGVSIATVSRVLNNSSSVTQQTRELVLQTVEQLGYRPNANAQALASQVSD
TIGVVVMDVSDPFFGAMVKAVDTVAQRLQKHVLINNSYHQEEKERHAIEVLIRQRCNALI
VHAKALSDEELAEFMDQVPGMVLINRLLPDYPHRCVCLDNVSGAMMATRMLLQQGHQRIG
YLRSSHPIADVTERLTGWRQALQEQGTEPPDEWIASGEPDLQGGEAAMVELLGRNQQLTA
VFAYNDGMAAGALMALKDNGITVPERFSVVGFDDIPISRYTDPRLTTIRYPIVSMAKIAT
ELALKGAAGLLDPTARHCFMPTLVRRHSVAAR