Protein Info for DDA3937_RS05890 in Dickeya dadantii 3937

Annotation: two-component system sensor histidine kinase RcsC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 953 transmembrane" amino acids 18 to 39 (22 residues), see Phobius details amino acids 307 to 310 (4 residues), see Phobius details amino acids 312 to 336 (25 residues), see Phobius details PF00512: HisKA" amino acids 470 to 534 (65 residues), 65.7 bits, see alignment 6.5e-22 PF02518: HATPase_c" amino acids 581 to 692 (112 residues), 94.1 bits, see alignment E=1.6e-30 PF09456: RcsC" amino acids 710 to 801 (92 residues), 115.8 bits, see alignment E=1.3e-37 PF00072: Response_reg" amino acids 830 to 938 (109 residues), 106 bits, see alignment E=2.6e-34

Best Hits

KEGG orthology group: K07677, two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC: 2.7.13.3] (inferred from 100% identity to ddd:Dda3937_01775)

Predicted SEED Role

"Two-component sensor protein RcsC (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SDZ2 at UniProt or InterPro

Protein Sequence (953 amino acids)

>DDA3937_RS05890 two-component system sensor histidine kinase RcsC (Dickeya dadantii 3937)
MPLKVIASFQTTLKVSRYMFRALATTLWILGALISIFYVNKELNQRESHLRQIFSLNFEQ
SLGYIRHTTDVARELRYIAANRLSTPVAPRERSTAKKTPSAIYPLSSTFDCSEQYEKNPA
QLQSLTGFFDQWHDDFSSVYDLNRIFFVDSSQQCIVDFGIRNQSLDSDSLMKSVQERLQN
QKSNRAGNRREESLFWVMPGPTPDSGYLYALTPVYVDNRLVTMMGIEQTIRLDDFMLNGD
LPFSVRLLDQNDRALLQFTDSQSGNSLSHYPDSNNYFGYSDGYGALLMKKALPPTSMTVV
YSLPLEVILMSLNTLIINIALLNLASAICLFLLTRLFERKIFLPAERNALQLEENEQFNR
KIVASAPVGICILRISDGTNIISNELAHNYLSLLTYEDRVRIVRIICEQQSKSLDVVTGR
NHHLQISFVHSRYRNENVAICVLLDVSARVRMEESLQEMANAAEQASQSKSMFLATVSHE
LRTPLYGIIGNLDLLQTKSLPSDANRLVTAMQNSSALLLKIISDILDFSKIESEQLKIEP
GEFAPREVINHIVSNYLPLVVKKRLVLYCYIDPNVPFRLLGDAVRLQQVLSNLLSNAIKF
TDTGCIVFQVACCDDGYLVFKMRDTGVGIDTRAVMKLFDPFFQAGTGVQRHFQGTGLGLA
ICEKLVSLMDGDITIESEPGLGSEFGIRIPLYRAHYPQTLQVPDLQGKTCWLQIRNAQME
RYLLGLLNACGLDARRYEDGQLVSRDDVMIFDHVPDALPNAHACVEISGMQAGAAQEVRA
GYWLYSTAALHELPVLLQRIYRGEDELSTAALSLPSVSYNRSENSDIRLLVVDDHPINRR
LLADQLGSLGYQVITANDGLDALDVLAKNPVDIILTDVNMPNMDGYRFTQRLREMEQTLP
VIGVTANALAEERQRCLQAGMDNCLSKPVTLDTLQQSLSYYSNLVRQNKSVQS