Protein Info for DDA3937_RS05845 in Dickeya dadantii 3937

Annotation: copper-exporting P-type ATPase CopA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 939 transmembrane" amino acids 282 to 300 (19 residues), see Phobius details amino acids 312 to 333 (22 residues), see Phobius details amino acids 345 to 368 (24 residues), see Phobius details amino acids 379 to 397 (19 residues), see Phobius details amino acids 531 to 553 (23 residues), see Phobius details amino acids 559 to 581 (23 residues), see Phobius details amino acids 877 to 896 (20 residues), see Phobius details amino acids 902 to 921 (20 residues), see Phobius details PF00403: HMA" amino acids 8 to 62 (55 residues), 45 bits, see alignment 2.4e-15 amino acids 72 to 128 (57 residues), 35.9 bits, see alignment 1.6e-12 amino acids 200 to 254 (55 residues), 58.2 bits, see alignment 1.8e-19 TIGR01511: copper-translocating P-type ATPase" amino acids 328 to 926 (599 residues), 598.1 bits, see alignment E=4.7e-183 TIGR01525: heavy metal translocating P-type ATPase" amino acids 347 to 926 (580 residues), 581.1 bits, see alignment E=7.3e-178 TIGR01494: HAD ATPase, P-type, family IC" amino acids 386 to 896 (511 residues), 272.3 bits, see alignment E=1.5e-84 PF00122: E1-E2_ATPase" amino acids 415 to 595 (181 residues), 160.9 bits, see alignment E=4.7e-51 PF00702: Hydrolase" amino acids 613 to 831 (219 residues), 125.7 bits, see alignment E=6.4e-40 PF08282: Hydrolase_3" amino acids 805 to 863 (59 residues), 28.3 bits, see alignment 2.9e-10

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to ddd:Dda3937_04159)

Predicted SEED Role

"Lead, cadmium, zinc and mercury transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5); Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.3, EC 3.6.3.4, EC 3.6.3.5)

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3, 3.6.3.4, 3.6.3.5

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.4 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SDY3 at UniProt or InterPro

Protein Sequence (939 amino acids)

>DDA3937_RS05845 copper-exporting P-type ATPase CopA (Dickeya dadantii 3937)
MSQTILLSLQGLSCEHCVGRVKKALEARPDVEQADVSLKYANVTGEADSQSLVATIEAAG
YEASPATVPNITLQLSGLNCQHCVASTRKALQAVPGVAATDVTLQQAAVYGDAEPLALVQ
AIEQAGFHVTLAQENTLPKSEPLTPHASSPDRLSAAFNPVPANTVHDDNVAHDDGNRIHD
NGGIHDISNVHDNDSVQLLLSGMSCASCVSRVQRALQSVPGVTQARVNLAERSALVSGDM
PHQALIDAVQNAGYGAEIILDEAERRARQEQTSRQAIRRFRWQAALGLALGIPLMVWGMI
GDNMMLTDDNRSGWLLVGGLTLAVMIAAGGHFYRNAWRSLINRSATMDTLVALGTGAAWL
YSITVNLWPAWFPMEARHLYYEASAMIIGLINLGHALEQGARQRSSQALERLLDLTPPTA
RLVTPQGDRVIPLAEVQTGMALRLTTGDRIPVDGLLEQGELWIDEAMLTGEPIPQQKAAG
DKVHAGTQVQDGSATLRAGAIGNQTTLARIIHLVRQAQSSKPAIGQLADRISAVFVPVVV
AIALLSGAIWYVVGPAPHIVYTLVIVTTVLIIACPCALGLATPMSIISGVGRAAELGVLV
RDADALQQASQLDVLVFDKTGTLTEGKPRVVAIHTFGDISESQALRWAASLEQGASHPLA
QAIVQRADGVELGDVTQFRTLPGLGVSGQVDGASLLLGNPALLAQHQIPLAGGENSPRDW
LEKQSALGMTPVLLVANGQVAALFSVQDTLRQDSISALQRLHRQGYQLVMLTGDNPTTAQ
AIAREAGIDQIIAGVLPDGKADAIRHLQSLGKRVAMIGDGINDAPALAQADVGIAMGGGS
DIAVETAAMTLMRHSLHGVADALALSRATLSNMKQNLLGAFVYNTLGIPIAAGVLYPLTG
TLLSPVVAGAAMALSSITVVSNANRLLRFTPADAPARRD