Protein Info for DDA3937_RS05650 in Dickeya dadantii 3937

Annotation: endopeptidase La

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 787 PF02190: LON_substr_bdg" amino acids 10 to 201 (192 residues), 203.1 bits, see alignment E=1.2e-63 TIGR00763: endopeptidase La" amino acids 12 to 771 (760 residues), 1049 bits, see alignment E=0 PF00004: AAA" amino acids 352 to 490 (139 residues), 75.3 bits, see alignment E=1.7e-24 PF07728: AAA_5" amino acids 352 to 484 (133 residues), 37.9 bits, see alignment E=4.3e-13 PF05362: Lon_C" amino acids 570 to 772 (203 residues), 328.5 bits, see alignment E=3.8e-102

Best Hits

Swiss-Prot: 93% identical to LON_ECOLI: Lon protease (lon) from Escherichia coli (strain K12)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 98% identity to dze:Dd1591_3066)

MetaCyc: 93% identical to Lon protease (Escherichia coli K-12 substr. MG1655)
Endopeptidase La. [EC: 3.4.21.53]

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SD71 at UniProt or InterPro

Protein Sequence (787 amino acids)

>DDA3937_RS05650 endopeptidase La (Dickeya dadantii 3937)
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEAST
DEPGVNDLFSVGTVASILQMLKLPDGTVKVLVEGLQRARITTLSDSGEHFAAQAEYLESP
AIEEREQEVLMRTAINQFEGYIKLNKKIPPEVLTSLNSIDDAARLADTIAAHMPLKLADK
QSVLEMSDVTERLEYLMAMMESEIDLLQVEKRIRSRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDAPDEQEALKRKIESASMPKEAREKAEAELQKLRMMSPMSAEATVVRSYIDWMVQ
VPWQARSKVKKDLVKAQEMLDSDHYGLERVKERILEYLAVQSRVSKIRGPILCLVGPPGV
GKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLF
LLDEIDKMSSDMRGDPASALLEVLDPEQNVAFNDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIARQHLLPKQIERNALKKGELTVEDSAIIGIIRYYTREAG
VRSLEREISKLCRKAVKSLMMDKALKHIQITGDNLKEYLGVQRYDYGRADEENRVGQVTG
LAWTEVGGDLLTIETASVPGKGKLTYTGSLGEVMQESIQAALTVVRARAEKLGINSDFYE
KRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGLVLPIGGLK
EKLLAAHRGGIKTVLIPEENKRDLEEIPQNVIADLEIHPVKRIEEVLTIALQNSPYGMDV
VKSVAKK