Protein Info for DDA3937_RS05620 in Dickeya dadantii 3937

Annotation: muropeptide MFS transporter AmpG

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 489 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details transmembrane" amino acids 48 to 68 (21 residues), see Phobius details amino acids 82 to 101 (20 residues), see Phobius details amino acids 107 to 128 (22 residues), see Phobius details amino acids 145 to 167 (23 residues), see Phobius details amino acids 173 to 194 (22 residues), see Phobius details amino acids 225 to 250 (26 residues), see Phobius details amino acids 262 to 281 (20 residues), see Phobius details amino acids 291 to 310 (20 residues), see Phobius details amino acids 321 to 343 (23 residues), see Phobius details amino acids 354 to 376 (23 residues), see Phobius details amino acids 382 to 401 (20 residues), see Phobius details amino acids 424 to 449 (26 residues), see Phobius details amino acids 463 to 484 (22 residues), see Phobius details PF13000: Acatn" amino acids 16 to 101 (86 residues), 38.8 bits, see alignment E=4.7e-14 PF07690: MFS_1" amino acids 17 to 365 (349 residues), 111.5 bits, see alignment E=4.3e-36 amino acids 241 to 487 (247 residues), 42.7 bits, see alignment E=3.6e-15 TIGR00901: AmpG-like permease" amino acids 25 to 363 (339 residues), 382.8 bits, see alignment E=9.7e-119

Best Hits

Swiss-Prot: 72% identical to AMPG_ECOLI: Anhydromuropeptide permease (ampG) from Escherichia coli (strain K12)

KEGG orthology group: K08218, MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG (inferred from 100% identity to ddd:Dda3937_01977)

MetaCyc: 72% identical to muropeptide:H+ symporter (Escherichia coli K-12 substr. MG1655)
TRANS-RXN0-226; TRANS-RXN0-258

Predicted SEED Role

"AmpG permease"

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SD65 at UniProt or InterPro

Protein Sequence (489 amino acids)

>DDA3937_RS05620 muropeptide MFS transporter AmpG (Dickeya dadantii 3937)
MLSRLLSLFREPNSVILLILGFASGLPLALTSGTLQAWMTVENVDLKTIGFFSLVGQAYV
FKFLWSPLMDRYTPPFMGRRRGWLLVTQLALVAAIVVIGTLNPSHHLWWLAMLAVIIAFC
SASQDIVFDAYKTDLLPPEERGSGAAISVLGYRLAMLVSGGLALWIADRFLGWHATYWLM
AGLLLLCTLATWLSPEPVVREPAPRSLEQAVFAPLKDFFSRNNAWLILMLIVLYKLGDAF
AVSLSTTFLIRGVGFNPGEVGLVNKTLGLFATIIGALYGGVLMQRWTLFRSLMLFGLLQA
VSNAGYWLLAVTDKQLVTMASAVFLENLCGGMGTAAFVALLMMLCNKSFSATQFALLSAL
SAVGRVYVGPIAGWFVELYGWAWFYLFSIIVAVPGLLLLKICRPSLEQTQSGGDFTRRNA
YPHFYALASRLFFIGCALFAGGLIAWGMMGLGWLGKAGVEKMLMAAGAILAVLAMLLGGM
LDYLSSRRR