Protein Info for DDA3937_RS05145 in Dickeya dadantii 3937

Annotation: phosphatidate cytidylyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 284 signal peptide" amino acids 1 to 19 (19 residues), see Phobius details transmembrane" amino acids 28 to 44 (17 residues), see Phobius details amino acids 56 to 74 (19 residues), see Phobius details amino acids 80 to 105 (26 residues), see Phobius details amino acids 117 to 137 (21 residues), see Phobius details amino acids 149 to 170 (22 residues), see Phobius details amino acids 191 to 210 (20 residues), see Phobius details amino acids 216 to 235 (20 residues), see Phobius details amino acids 263 to 281 (19 residues), see Phobius details PF01148: CTP_transf_1" amino acids 4 to 278 (275 residues), 248.9 bits, see alignment E=4.1e-78

Best Hits

Swiss-Prot: 70% identical to CDSA_ECO57: Phosphatidate cytidylyltransferase (cdsA) from Escherichia coli O157:H7

KEGG orthology group: K00981, phosphatidate cytidylyltransferase [EC: 2.7.7.41] (inferred from 100% identity to ddd:Dda3937_04310)

MetaCyc: 70% identical to CDP-diglyceride synthetase (Escherichia coli K-12 substr. MG1655)
Phosphatidate cytidylyltransferase. [EC: 2.7.7.41]; 2.7.7.41 [EC: 2.7.7.41]

Predicted SEED Role

"Phosphatidate cytidylyltransferase (EC 2.7.7.41)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.7.41)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.7.41

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SCD5 at UniProt or InterPro

Protein Sequence (284 amino acids)

>DDA3937_RS05145 phosphatidate cytidylyltransferase (Dickeya dadantii 3937)
MLKYRLITALILIPLVIAALFFLPPLVFSLVTLAVCMLAAWEWGQLAGLVSYTQRIWLSI
ACGFVLAAMLLSLPDYHYSVALAPVCLLWLSLAWWSVALLMVLFYPSSAALWRHSRVLRL
CFGLLTIVPFFWGMVALRQFEYETNPFSGAWWLLYVMVLVWGADSGAYLFGKLFGRHKLA
PKVSPGKTWEGFIGGLATSAVIALLFSHYAPLSISTFTLLVCSVVATLASVLGDLTESMF
KREAGIKDSSHLIPGHGGILDRIDSLTAAIPVFACLMLLLFKAV