Protein Info for DDA3937_RS05100 in Dickeya dadantii 3937

Annotation: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 274 PF14805: THDPS_N_2" amino acids 3 to 69 (67 residues), 99 bits, see alignment E=2.1e-32 TIGR00965: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase" amino acids 3 to 273 (271 residues), 532.7 bits, see alignment E=8.9e-165 PF00132: Hexapep" amino acids 175 to 209 (35 residues), 29.7 bits, see alignment 5.5e-11 PF14602: Hexapep_2" amino acids 175 to 209 (35 residues), 50.5 bits, see alignment 2e-17

Best Hits

Swiss-Prot: 94% identical to DAPD_YERE8: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD) from Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)

KEGG orthology group: K00674, 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase [EC: 2.3.1.117] (inferred from 100% identity to ddd:Dda3937_00876)

MetaCyc: 93% identical to tetrahydrodipicolinate succinylase (Escherichia coli K-12 substr. MG1655)
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase. [EC: 2.3.1.117]

Predicted SEED Role

"2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (EC 2.3.1.117)" in subsystem Lysine Biosynthesis DAP Pathway (EC 2.3.1.117)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.117

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SCC6 at UniProt or InterPro

Protein Sequence (274 amino acids)

>DDA3937_RS05100 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (Dickeya dadantii 3937)
MQQLQNIIETAFERRADITPANVDTVTREAVNQVISQLDSGMLRVAEKINGQWVTHQWLK
KAVLLSFRINDNQLMEGAETRYYDKVPMKFAGYDEARFQREGFRVVPPASVRQGAFIARN
TVLMPSYVNIGAYVDEGSMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQANPTIIED
NCFIGARSEVVEGVIVEEGSVISMGVFISQSTRIYDRETGEIHYGRVPAGSVVVSGNLPA
KDGSHSLYCAVIVKKVDAKTRGKVGINELLRTID