Protein Info for DDA3937_RS04385 in Dickeya dadantii 3937

Annotation: insulinase family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 924 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF00675: Peptidase_M16" amino acids 53 to 164 (112 residues), 67.7 bits, see alignment E=1.1e-22 PF05193: Peptidase_M16_C" amino acids 206 to 383 (178 residues), 53.9 bits, see alignment E=2.1e-18 amino acids 699 to 852 (154 residues), 35 bits, see alignment E=1.3e-12

Best Hits

KEGG orthology group: K07263, zinc protease [EC: 3.4.24.-] (inferred from 100% identity to ddd:Dda3937_01405)

Predicted SEED Role

"Probable zinc protease pqqL (EC 3.4.99.-)" (EC 3.4.99.-)

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-, 3.4.99.-

Use Curated BLAST to search for 3.4.24.- or 3.4.99.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SB26 at UniProt or InterPro

Protein Sequence (924 amino acids)

>DDA3937_RS04385 insulinase family protein (Dickeya dadantii 3937)
MRKMTSRWSGIIGFCLFSTLASAQTVTSPLPVITEGQLDNGLRYTIVPLAGQQQRLDIRL
SVESGSLDEQDGESGVAHMVEHMVFRATRDYPAGLAQTLGQQGWVRAQHYNAMTNYERTV
YMLSPPAGKPSLGLALNVLAQIAGQARFEPEDWQRERQVILEEWRGKLGVAERMNQQRVA
AIRHGSRYPDRPVIGSEHAIQTTPATVLRNFYSRWYHPRNMRLLVIGDLEPEQVKQAIMQ
AMGTLPDGKIPQRDQYEPALHPQLHVVRLQDSQSSVSQVSLVFRFDDAAARATGEQGLRH
RLINQIALDTLSRQVQRQPISPATAVSSLVVRKSDIGRTTVALGLFASVLPDGHQQGLNV
LLQEIARLQRYPLYESDIAAVKDEIRQSAQNMAATPEQREFSDWVQQLVVSWQQERPYTG
KQQLGQQALAALNSITAADINACLQRWLSSPDQLVQFSVPGNLPFTLPSAADVEQLRQQV
ARGELSPLQQSVVRVAPTLPAADGHGAVTSVRSFPEQKVEEWQLSNGDRLVWLRSVQAGK
AVSLTVQSPAGFMTPGREPWLSQLAGQLISQSGPAGWKGRDLTDWKKEQRLSLSLDYQPD
ALRWSGSVSPDKLDALLHLYHAMNRSAAINENDMRDSLSVLKRQQVTREQSVGFRREQEI
AMLQFGKTTTPFPTSAQLDTVTTEQLAQQWRQTVAAPVTYYLLADLPAERLRPLVERYLA
SLPRQAGAESPQNLTLPGKRERVSAINLEPKADIYLWSFSPQPWTPQQAVQVNIASRLAA
RYLKASLRDDAQGIYNLKMESRLNDNSQRVETLLRFTTSPQRAQELRRNAQQVLETLATR
ITPQDVEQERQQFIRSERARQQDNSTLMSRLMLSYHNYHDPRYLTQLDSLAPAITIEAVR
EAASRLWHPQNQVLYITLPREKKS