Protein Info for DDA3937_RS03700 in Dickeya dadantii 3937

Annotation: inositol 2-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 328 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details TIGR04380: inositol 2-dehydrogenase" amino acids 1 to 326 (326 residues), 449.2 bits, see alignment E=3.6e-139 PF01408: GFO_IDH_MocA" amino acids 2 to 119 (118 residues), 81 bits, see alignment E=1.2e-26 PF02894: GFO_IDH_MocA_C" amino acids 136 to 328 (193 residues), 69.2 bits, see alignment E=4.5e-23

Best Hits

Swiss-Prot: 49% identical to IOLG_THEMA: Myo-inositol 2-dehydrogenase (iolG) from Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)

KEGG orthology group: K00010, myo-inositol 2-dehydrogenase [EC: 1.1.1.18] (inferred from 100% identity to ddd:Dda3937_01203)

MetaCyc: 49% identical to myo-inositol 2-dehydrogenase (Thermotoga maritima)
Inositol 2-dehydrogenase. [EC: 1.1.1.18]

Predicted SEED Role

"Myo-inositol 2-dehydrogenase 1 (EC 1.1.1.18)" in subsystem Inositol catabolism (EC 1.1.1.18)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.18

Use Curated BLAST to search for 1.1.1.18

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SMN0 at UniProt or InterPro

Protein Sequence (328 amino acids)

>DDA3937_RS03700 inositol 2-dehydrogenase (Dickeya dadantii 3937)
MFNIALLGAGRIGQVHAVNIAEHRETCLYSVVDPNLANARALSDKYQARLQTVDEAMADP
AVHAVLIASATDTHADLIELAARHGKAIFCEKPVHLDIARVRDCLKVVEQQQVPLFVGFN
RRYDPQFRRVKTLAGEGCIGKPESLMIISRDPSPPPAEYVRVSGGMFRDMTIHDFDMVRF
IMGEEPVSVFAQGSNLVDPAIGAAGDIDTAFVVFKFASGAMATIVNSRRSGYGYDQRLEL
HGERGVLSAGNIRENQVEHWGDVGCLAAKPEHFFLQRYRDAYAAEWRHFVEVLHGRTQPE
CSGVDGERALYLADKALESLATGRAVSL