Protein Info for DDA3937_RS03135 in Dickeya dadantii 3937

Annotation: deoxyribose-phosphate aldolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 83% identical to DEOC_SERP5: Deoxyribose-phosphate aldolase (deoC) from Serratia proteamaculans (strain 568)

KEGG orthology group: K01619, deoxyribose-phosphate aldolase [EC: 4.1.2.4] (inferred from 100% identity to ddd:Dda3937_02328)

MetaCyc: 78% identical to deoxyribose-phosphate aldolase (Escherichia coli K-12 substr. MG1655)
Deoxyribose-phosphate aldolase. [EC: 4.1.2.4]

Predicted SEED Role

"Deoxyribose-phosphate aldolase (EC 4.1.2.4)" in subsystem Deoxyribose and Deoxynucleoside Catabolism (EC 4.1.2.4)

MetaCyc Pathways

superpathway of purine deoxyribonucleosides degradation (7/7 steps found)
superpathway of pyrimidine deoxyribonucleosides degradation (6/6 steps found)
2-deoxy-α-D-ribose 1-phosphate degradation (3/3 steps found)
2-deoxy-D-ribose degradation I (3/3 steps found)

KEGG Metabolic Maps

Pentose phosphate pathway

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.1.2.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SKZ4 at UniProt or InterPro

Protein Sequence (259 amino acids)

>DDA3937_RS03135 deoxyribose-phosphate aldolase (Dickeya dadantii 3937)
MTDLTAAAQRALGLMDLTTLNDDDTDEKVIALCRQANSPAGKTAAICIYPRFVPLARKVL
REQGTPDVRIATVTNFPHGNDDIDIALAETKAAIAYGADDVDVVFPYRALMAGNRQVGFD
LVKACKAACEAAGVLLKVIIETGELKTDALIREASEIAIDAGADFIKTSTGKVAVNATLH
SADVMLNVIRDKGVGERVGFKPAGGVRTAEDAADYLQLADAIMGDGWADARHFRFGASGL
LGSLLTTLGHAAGQARSGY