Protein Info for DDA3937_RS01800 in Dickeya dadantii 3937
Annotation: alcohol dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 77% identical to YQHD_ECOLI: Alcohol dehydrogenase YqhD (yqhD) from Escherichia coli (strain K12)
KEGG orthology group: K08325, NADP-dependent alcohol dehydrogenase [EC: 1.1.-.-] (inferred from 100% identity to ddd:Dda3937_01258)MetaCyc: 77% identical to NADPH-dependent aldehyde reductase YqhD (Escherichia coli K-12 substr. MG1655)
Aldehyde reductase. [EC: 1.1.1.21]; Alcohol dehydrogenase (NADP(+)). [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.2 [EC: 1.1.1.21, 1.1.1.2]; 1.1.1.- [EC: 1.1.1.21, 1.1.1.2]
Predicted SEED Role
"Hypothetical oxidoreductase YqhD (EC 1.1.-.-)" in subsystem D-gluconate and ketogluconates metabolism (EC 1.1.-.-)
MetaCyc Pathways
- glycerol degradation to butanol (12/16 steps found)
- methylglyoxal degradation III (1/2 steps found)
- 1,3-propanediol biosynthesis (engineered) (6/9 steps found)
- pyruvate fermentation to butanol I (5/8 steps found)
- D-arabinose degradation V (1/3 steps found)
- D-xylose degradation to ethylene glycol (engineered) (1/4 steps found)
- L-tryptophan degradation X (mammalian, via tryptamine) (1/4 steps found)
- superpathway of Clostridium acetobutylicum solventogenic fermentation (7/13 steps found)
- superpathway of methylglyoxal degradation (3/8 steps found)
- superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (9/17 steps found)
- detoxification of reactive carbonyls in chloroplasts (1/10 steps found)
- superpathway of pentose and pentitol degradation (12/42 steps found)
KEGG Metabolic Maps
- 1- and 2-Methylnaphthalene degradation
- Benzoate degradation via CoA ligation
- Bisphenol A degradation
- Caprolactam degradation
- Ethylbenzene degradation
- Fructose and mannose metabolism
- Galactose metabolism
- Glycerolipid metabolism
- Glycolysis / Gluconeogenesis
- Limonene and pinene degradation
- Naphthalene and anthracene degradation
- Pentose and glucuronate interconversions
- Pyruvate metabolism
- Retinol metabolism
- gamma-Hexachlorocyclohexane degradation
Isozymes
Compare fitness of predicted isozymes for: 1.1.-.-
Use Curated BLAST to search for 1.1.-.- or 1.1.1.2 or 1.1.1.21
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See E0SI62 at UniProt or InterPro
Protein Sequence (387 amino acids)
>DDA3937_RS01800 alcohol dehydrogenase (Dickeya dadantii 3937) MQNFTLHTPTKILFGEGQIASLADQIPADARILITYGGGSIKKNGVFDQVINALKGRNVL EFSGIEPNPTYETLMKAVEIVRKEKIDFLLAVGGGSVADGTKFIAAAAHYTAADDPWHIL QTWGAQIETATPLGVVLTLPATGSESNSGAVITRKSSGDKQAFMNPLVCPRFAVLDPVVT YTLPERQIANGVVDAFVHTVEQYLTYPANAKVQDRFAEGLLLTLIEEGPRALKEQHNYDV RANVMWSATMALNGLIGAGVPQDWSTHMLGHEITAMHGLDHAQTLAIVLPAMLNERRVQK REKLLQYAERVWNLRDGSEDQRIDAAIAATRAFFEQMGVPTRLSDYQLDGSSIPAMVAKL EEHGMTALGEHHDITLDISRRVYEAAR