Protein Info for DDA3937_RS01640 in Dickeya dadantii 3937

Annotation: multidrug effflux MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 417 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 54 to 74 (21 residues), see Phobius details amino acids 81 to 100 (20 residues), see Phobius details amino acids 108 to 128 (21 residues), see Phobius details amino acids 140 to 164 (25 residues), see Phobius details amino acids 170 to 190 (21 residues), see Phobius details amino acids 222 to 243 (22 residues), see Phobius details amino acids 263 to 283 (21 residues), see Phobius details amino acids 293 to 315 (23 residues), see Phobius details amino acids 321 to 342 (22 residues), see Phobius details amino acids 352 to 373 (22 residues), see Phobius details amino acids 382 to 401 (20 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 15 to 401 (387 residues), 270.3 bits, see alignment E=1.8e-84 PF07690: MFS_1" amino acids 20 to 368 (349 residues), 156.6 bits, see alignment E=4.3e-50

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 100% identity to ddd:Dda3937_00704)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SHE5 at UniProt or InterPro

Protein Sequence (417 amino acids)

>DDA3937_RS01640 multidrug effflux MFS transporter (Dickeya dadantii 3937)
MSERYEHSAAAMTYSLILLLALLTALDAMAIDMYLPAMPALAMDFGASSGKVQQTLSVFL
VGLALGQGICGPLLDRYGRRIPLLAGLVIFIGGSVMAALSSSIEWLMLARFLQALGASAG
LVAPRAIVADLYSVAESARIFSLLMQVMMIAPILAPLLGGYLLAHGEWRLVFWVLAGLGG
AGLIWGIRTIPESLSEEKRLASRAGNLSPGNIVRAYVRQLGYGVFMAYTLAGGVIFGSLF
VYISSSSFVFTQSFGLTPAQFSYIFAANAVSLVIGGQISTTLLRRRVGEQRIMMFGIVIH
ILAGLVLSVLILSGWIGLWGYLLLLATAIGALGLVFGNLTALTMAYAGRQAGVASALMGM
LQYLIAALVGYCASQVLQGPVVLPVVIVLCGVVAMLLCIMASHMAQAAFSTCYDDRE