Protein Info for DDA3937_RS00895 in Dickeya dadantii 3937

Annotation: aquaporin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 283 transmembrane" amino acids 16 to 41 (26 residues), see Phobius details amino acids 48 to 81 (34 residues), see Phobius details amino acids 88 to 110 (23 residues), see Phobius details amino acids 147 to 168 (22 residues), see Phobius details amino acids 180 to 203 (24 residues), see Phobius details amino acids 232 to 253 (22 residues), see Phobius details PF00230: MIP" amino acids 8 to 253 (246 residues), 218.9 bits, see alignment E=3.8e-69 TIGR00861: MIP family channel proteins" amino acids 15 to 253 (239 residues), 241.7 bits, see alignment E=4e-76

Best Hits

Swiss-Prot: 80% identical to GLPF_ECOL6: Glycerol uptake facilitator protein (glpF) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K02440, glycerol uptake facilitator protein (inferred from 100% identity to ddd:Dda3937_03877)

MetaCyc: 80% identical to glycerol facilitator (Escherichia coli K-12 substr. MG1655)
RXN0-7189; RXN0-7191; TRANS-RXN-131; TRANS-RXN0-460; TRANS-RXN0-536; TRANS-RXN0-537; TRANS-RXN0-551

Predicted SEED Role

"Glycerol uptake facilitator protein" in subsystem Glycerol and Glycerol-3-phosphate Uptake and Utilization or Glycerol fermenation to 1,3-propanediol

MetaCyc Pathways

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SFN1 at UniProt or InterPro

Protein Sequence (283 amino acids)

>DDA3937_RS00895 aquaporin (Dickeya dadantii 3937)
MSQSELSTLKGQCIAEFLGTGLLIFFGVGCVAALKLAGASLGLWEISIIWGLGVAMAIYL
TAAISGAHLNPAVTIALWLFACFDGRKVLPYIVSQVAGAFCSAALVYGLYHNLFDNIEQT
HNMVRGSVESLDLAGIFSTYPNPHISVLQAFLVETVITAILMCLILALTDDGNGIPRGPL
APLLIGILIAIIGASMGPLTGFAMNPARDAGPKLFAYFAGWGKIALTGGRDIPYILIPIF
GPIVGACLGAFGYRSLIGRNLPCDVCATDTDTDTAASAQTRKV