Protein Info for DDA3937_RS00515 in Dickeya dadantii 3937

Annotation: EamA family transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 302 transmembrane" amino acids 7 to 27 (21 residues), see Phobius details amino acids 33 to 51 (19 residues), see Phobius details amino acids 61 to 82 (22 residues), see Phobius details amino acids 88 to 108 (21 residues), see Phobius details amino acids 116 to 136 (21 residues), see Phobius details amino acids 143 to 164 (22 residues), see Phobius details amino acids 176 to 198 (23 residues), see Phobius details amino acids 218 to 237 (20 residues), see Phobius details amino acids 246 to 266 (21 residues), see Phobius details amino acids 272 to 294 (23 residues), see Phobius details PF00892: EamA" amino acids 7 to 130 (124 residues), 64.1 bits, see alignment E=8.3e-22 amino acids 147 to 288 (142 residues), 54.4 bits, see alignment E=8.7e-19

Best Hits

Swiss-Prot: 64% identical to EAMA_SALTY: Probable amino-acid metabolite efflux pump (eamA) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K03298, drug/metabolite transporter, DME family (inferred from 100% identity to ddd:Dda3937_01986)

MetaCyc: 61% identical to cysteine/O-acetylserine exporter EamA (Escherichia coli K-12 substr. MG1655)
RXN0-1923; RXN0-1924

Predicted SEED Role

"Permease of the drug/metabolite transporter (DMT) superfamily" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SES0 at UniProt or InterPro

Protein Sequence (302 amino acids)

>DDA3937_RS00515 EamA family transporter (Dickeya dadantii 3937)
MTIKDQLLALCVVVVWGVNFVVMKIGLHDMPPFLLAGLRFLLVALPAVLLVPRPALPLRW
LAAYGMTISFGQFAFLFCAIKMGMPVGMASLVIQSQAFFTLMLGAWWLGERLQWNQWLGI
LVAALGMVVLAEGNAANASLPGMTLTTLLLTLAAAASWACGNICNKQIMRHHPVNAMSLV
VWSALIPVGPFLLCSWLFEGADTIVASLTSIRLPTVLALMYLSFISTLIGYAIWGNLLAR
YETWRVAPLSLLVPVVGILSAALLLGEHLSTGQLLGALLVMLGLLVNVFGARLWPLRSAR
QP