Protein Info for DDA3937_RS00455 in Dickeya dadantii 3937

Annotation: 2-hydroxycarboxylate transporter family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 447 transmembrane" amino acids 32 to 54 (23 residues), see Phobius details amino acids 59 to 77 (19 residues), see Phobius details amino acids 86 to 108 (23 residues), see Phobius details amino acids 123 to 144 (22 residues), see Phobius details amino acids 151 to 173 (23 residues), see Phobius details amino acids 180 to 207 (28 residues), see Phobius details amino acids 215 to 240 (26 residues), see Phobius details amino acids 274 to 294 (21 residues), see Phobius details amino acids 300 to 318 (19 residues), see Phobius details amino acids 330 to 351 (22 residues), see Phobius details amino acids 357 to 383 (27 residues), see Phobius details amino acids 426 to 446 (21 residues), see Phobius details PF03390: 2HCT" amino acids 31 to 440 (410 residues), 503.7 bits, see alignment E=1.8e-155

Best Hits

Swiss-Prot: 60% identical to MAEN_BACSU: Na(+)-malate symporter (maeN) from Bacillus subtilis (strain 168)

KEGG orthology group: K11616, malate:Na+ symporter (inferred from 100% identity to ddd:Dda3937_02539)

Predicted SEED Role

"Citrate-sodium symport"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See E0SEQ8 at UniProt or InterPro

Protein Sequence (447 amino acids)

>DDA3937_RS00455 2-hydroxycarboxylate transporter family protein (Dickeya dadantii 3937)
MKNIETEIMSDNTLATTAPSGLLESLNKTRIGSVPFILFLVISAVVFIAAYASYLPKNMI
GGFAVIMTMGFLLAYIGQRIPVLKEIGGPAILCLMVPSILVYFHLFNANTLDTVKLLMKD
ANFLYFVIASLVVGSILGMNRVILIQGMIRMFIPLVIGTAAAVVTGLLVGKLFGYSFYHT
FFFIIVPIIGGGIGEGILPLSLAYSAILGQAPDVYVAQLVPAAVVGNIFAIICAGVLARI
GVWRSDLNGNGNLVRNEADNALFAVKDAPKTVDFHLMGGGLLLICTFFIVGGLFEKVLHI
PGPVLMILIAVLCKYGRVIPSSMETGANSFYKFVSSSLVWPLMIGLGMLYVPLESVVAVF
SVGYVVVCGSVVLSMALISFFIAPYLKMYPVEASIVTSCHSGLGGTGDVAILSASNRMSL
MPFAQIATRIGGASTVIAATLLLGWLV