Protein Info for COO64_RS09875 in Pseudomonas sp. SVBP6

Name: pabB
Annotation: aminodeoxychorismate synthase component I

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF04715: Anth_synt_I_N
  • amino acids 13 to 138 (126 residues), 66.9 bits, E=2.3e-22
• TIGR00553: aminodeoxychorismate synthase, component I
  • amino acids 93 to 440 (348 residues), 361.7 bits, E=1.8e-112
• PF00425: Chorismate_bind
  • amino acids 182 to 436 (255 residues), 302.2 bits, E=3.4e-94

Best Hits

KEGG orthology group: K01665, para-aminobenzoate synthetase component I [EC: 2.6.1.85] (inferred from 80% identity to pen:PSEEN1897)

Predicted SEED Role

"Para-aminobenzoate synthase, aminase component (EC 2.6.1.85)" in subsystem Chorismate: Intermediate for synthesis of PAPA antibiotics, PABA, anthranilate, 3-hydroxyanthranilate and more. or Folate Biosynthesis (EC 2.6.1.85)

MetaCyc Pathways

• superpathway of tetrahydrofolate biosynthesis and salvage (10/12 steps found)
• L-asparagine biosynthesis III (tRNA-dependent) (4/4 steps found)
• glutaminyl-tRNA^gln biosynthesis via transamidation (4/4 steps found)
• L-glutamate and L-glutamine biosynthesis (6/7 steps found)
• ammonia assimilation cycle III (3/3 steps found)
• superpathway of tetrahydrofolate biosynthesis (8/10 steps found)
• 4-aminobenzoate biosynthesis I (2/2 steps found)
• L-glutamate biosynthesis I (2/2 steps found)
• L-glutamine degradation I (1/1 steps found)
• L-citrulline biosynthesis (6/8 steps found)
• superpathway of chorismate metabolism (42/59 steps found)
• superpathway of L-citrulline metabolism (8/12 steps found)
• superpathway of candicidin biosynthesis (4/11 steps found)
• chloramphenicol biosynthesis (1/9 steps found)

KEGG Metabolic Maps

• Biosynthesis of phenylpropanoids
• Folate biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.85

Use Curated BLAST to search for 2.6.1.85

Protein Sequence (447 amino acids)

>COO64_RS09875 aminodeoxychorismate synthase component I (Pseudomonas sp. SVBP6)
MPTCTLHPLPYQADPAAYFARIRKAPGAVLLDSARPTAERGRFDLLSAWPLQTLAPTVDE
SGSAYLQRLRDSLTQLGRAQVPDGVELPFAGGLIGYLSYDFGRRLEHLSSVAVDDLGLAD
ASLGLYAWALISDHQQQHSQLLFHPSLAEAERQRLIELFEAPATVDTASFALQAPMRGDI
SAEHYRQAFDRVQQYIHAGDCYQINLTQRFRAPCQGAPWHAYQALRQACPTPYSGFQLLA
DGSALLSFSPERFIRVSNGQVETRPIKGTRPRSSDAGEDARNAAELLGSSKDRAENLMIV
DLLRNDLGRTCEIGSVKVPELFSLESYPNVHHLVSSVTGRLAAGKDALDLIADSFPGGSI
TGAPKIRAMQIIDELEPSRRALYCGSLLYVDVRGEMDSSIAIRSLLVKDAQVCCWGGGAV
VADSDWQAEYEESITKVKVLLETLQSL