Protein Info for COO64_RS06980 in Pseudomonas sp. SVBP6

Annotation: carboxy terminal-processing peptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 695 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details PF17804: TSP_NTD" amino acids 47 to 234 (188 residues), 222.4 bits, see alignment E=1.2e-69 TIGR00225: C-terminal processing peptidase" amino acids 203 to 560 (358 residues), 313.4 bits, see alignment E=8.4e-98 PF00595: PDZ" amino acids 242 to 321 (80 residues), 32.1 bits, see alignment E=2.5e-11 PF03572: Peptidase_S41" amino acids 365 to 538 (174 residues), 164.9 bits, see alignment E=2.5e-52 PF11818: DUF3340" amino acids 543 to 684 (142 residues), 143.8 bits, see alignment E=9.9e-46

Best Hits

KEGG orthology group: K03797, carboxyl-terminal processing protease [EC: 3.4.21.102] (inferred from 92% identity to ppu:PP_1719)

Predicted SEED Role

"Periplasmic protease"

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.102

Use Curated BLAST to search for 3.4.21.102

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (695 amino acids)

>COO64_RS06980 carboxy terminal-processing peptidase (Pseudomonas sp. SVBP6)
MKHFLPSTTLALLIGLGSLPLAGSAWAANSWDKLQPDRDEVVASLNVVELLKRHHYSKPP
LNDARSVIIYDSYLKLLDPARSYFTASDIAEFDKWKTQFDDFLKSGNLDPGFTIYKRYLD
RVKSRLDFALAELSKGVDNFDFTTKESLLIDRKDAPWMKTQAELDDLWRKRVKDEVLRLK
IAGKEPKAIQELLTKRYKNQLTRLDQTRAEDIFQAYINTFAQSYDPHTNYLSPDNAENFD
INMSLSLEGIGAVLQSDNDQVKIVRLVPAGPAAKTKQVAPADKIIGVAQGNKEMVDVIGW
RLDEVVKLIRGPKGSVVRLEIIPASNAPNDQTTKIVPITREAVKLEEQAAKKSVLKLKQD
GRDYKLGIIEIPAFYLDFKAFRAGDPEYKSTTRDVKKLLTELQKEKVDGVVIDLRNNGGG
SLQEATELTSLFIDKGPTVLVRNSDGRVDVLEDENNGAFYKGPLALVVNRLSASASEIFA
GAMQDYHRALILGGQTFGKGTVQTIQPLNHGELKLTLAKFYRVSGQSTQHQGVLPDIDYP
SIIDTKEIGESALPEAMPWDTIRPAIKPALDPFKPFLAQLKARHDTRTAKDPEFVYIRDR
LALTQKLMNEKTVSLNEAERRAQHADIESKQLALENTRRKAKGEEPLKELKKEDEDALPV
EPDDTKPEDDAYLAESGRILLDYLGLNTAVAKNNP