Protein Info for CCNA_03845 in Caulobacter crescentus NA1000 Δfur

Annotation: ADA regulatory protein/O6-methylguanine-DNA methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 PF12833: HTH_18" amino acids 56 to 133 (78 residues), 57 bits, see alignment E=3.1e-19 PF01035: DNA_binding_1" amino acids 216 to 296 (81 residues), 101.2 bits, see alignment E=3.4e-33 TIGR00589: methylated-DNA--[protein]-cysteine S-methyltransferase" amino acids 216 to 294 (79 residues), 96 bits, see alignment E=5.2e-32

Best Hits

KEGG orthology group: K10778, AraC family transcriptional regulator, regulatory protein of adaptative response / methylated-DNA-[protein]-cysteine methyltransferase [EC: 2.1.1.63] (inferred from 100% identity to ccs:CCNA_03845)

Predicted SEED Role

"ADA regulatory protein / Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63)" in subsystem DNA repair, bacterial (EC 2.1.1.63)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.63

Use Curated BLAST to search for 2.1.1.63

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CEI2 at UniProt or InterPro

Protein Sequence (300 amino acids)

>CCNA_03845 ADA regulatory protein/O6-methylguanine-DNA methyltransferase (Caulobacter crescentus NA1000 Δfur)
MTMAYDASSLSDAISEAARQELARLAERSVDYHRMAKALDWLAERWSDHPPLDDAAQAVG
LSPFHFQRIFTRWAGVSPKTFVSAIAHAEARRSLEAGGTVLDAAFDAGLSGPSRLHDLFI
AQEAATPGEVRRRGAGMRLRWGWAPTPFGRGLFVMADRGLAGLAFSDGDDEASFADMHRR
FPAADWSRDDLAAQATALHAFAGGEGPLPVVLIGSPFHVQVWKALLRIPTGETATYGQVA
AWAGKPKAFHATGGAIGANPISLLIPCHRAIAKDGRLTGYHWGLARKAAMLGMEAVAAAS