Protein Info for CCNA_03695 in Caulobacter crescentus NA1000 Δfur

Annotation: aldehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

Best Hits

Swiss-Prot: 81% identical to ALDH_PARDP: Aldehyde dehydrogenase (adh) from Paracoccus denitrificans (strain Pd 1222)

KEGG orthology group: K00128, aldehyde dehydrogenase (NAD+) [EC: 1.2.1.3] (inferred from 100% identity to ccs:CCNA_03695)

MetaCyc: 81% identical to aldehyde dehydrogenase (NAD+) (Paracoccus denitrificans PD1222)
Aldehyde dehydrogenase (NAD(+)). [EC: 1.2.1.3]

Predicted SEED Role

"Aldehyde dehydrogenase B (EC 1.2.1.22)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria or Methylglyoxal Metabolism (EC 1.2.1.22)

MetaCyc Pathways

ethanol degradation II (3/3 steps found)
ethanol degradation IV (3/3 steps found)
L-lactaldehyde degradation (aerobic) (2/2 steps found)
superpathway of NAD/NADP - NADH/NADPH interconversion (yeast) (6/8 steps found)
phytol degradation (3/4 steps found)
ethanol degradation III (2/3 steps found)
hypotaurine degradation (2/3 steps found)
methylglyoxal degradation IV (2/3 steps found)
methylglyoxal degradation V (2/3 steps found)
mitochondrial NADPH production (yeast) (3/5 steps found)
superpathway of methylglyoxal degradation (5/8 steps found)
L-tryptophan degradation X (mammalian, via tryptamine) (2/4 steps found)
fatty acid α-oxidation I (plants) (2/4 steps found)
putrescine degradation III (2/4 steps found)
serotonin degradation (4/7 steps found)
histamine degradation (1/3 steps found)
3-methyl-branched fatty acid α-oxidation (3/6 steps found)
noradrenaline and adrenaline degradation (8/13 steps found)
dopamine degradation (2/5 steps found)
lactate biosynthesis (archaea) (2/5 steps found)
octane oxidation (2/5 steps found)
aromatic biogenic amine degradation (bacteria) (3/8 steps found)
ceramide degradation by α-oxidation (2/7 steps found)
sphingosine and sphingosine-1-phosphate metabolism (4/10 steps found)
alkane oxidation (1/6 steps found)
L-rhamnose degradation II (2/8 steps found)
limonene degradation IV (anaerobic) (1/7 steps found)
superpathway of fucose and rhamnose degradation (4/12 steps found)
ceramide and sphingolipid recycling and degradation (yeast) (4/16 steps found)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.2.1.22, 1.2.1.3

Use Curated BLAST to search for 1.2.1.22 or 1.2.1.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CCV8 at UniProt or InterPro

Protein Sequence (506 amino acids)

>CCNA_03695 aldehyde dehydrogenase (Caulobacter crescentus NA1000 Δfur)
MTKPEFIESLSRPPFKARYDNFIGGQWVAPADGRYFDNSSPIHGRKICEIARSQAIDIER
ALDAAHAAKAGWARTSAADRSRILLRIADRMEENLAALATAETWDNGKPIRETLAADIPL
AIDHFRYFAGCLRSQEGSISEIDHDTIAYHFHEPLGVVGQIIPWNFPLLMACWKLAPALA
AGNCVVLKPAEQTPASIMVWAEMIGDLLPAGVLNIVNGFGLEAGKPLASSPRIAKIAFTG
ETSTGRLIMQYAAQNLIPVTLELGGKSPNIFFDDVAREDDDYLDKALEGFTMFALNQGEV
CTCPSRALVQESIYEKFMERALKRVNAVVQGSPLDPATMIGAQASEEQLNKILGYMDIGR
NEGAKLLAGGQRKILPGQLADGYYVEPTVFEGHNKMRIFQEEIFGPVLAVTTFKTEEEAL
EIANDTAFGLGAGVWSRDANRCYRFGRGIEAGRVWTNCYHAYPAHAAFGGYKQSGVGRET
HKMMLDHYQQTKNMLVSYSPKALGFF