Protein Info for CCNA_03562 in Caulobacter crescentus NA1000 Δfur

Annotation: ATP synthase alpha chain

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 510 TIGR00962: ATP synthase F1, alpha subunit" amino acids 3 to 509 (507 residues), 837.2 bits, see alignment E=2.3e-256 PF02874: ATP-synt_ab_N" amino acids 25 to 93 (69 residues), 63.9 bits, see alignment E=2.5e-21 PF00006: ATP-synt_ab" amino acids 150 to 373 (224 residues), 269.6 bits, see alignment E=3e-84 PF00306: ATP-synt_ab_C" amino acids 380 to 505 (126 residues), 169.5 bits, see alignment E=6.1e-54

Best Hits

Swiss-Prot: 100% identical to ATPA_CAUVN: ATP synthase subunit alpha (atpA) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: K02111, F-type H+-transporting ATPase subunit alpha [EC: 3.6.3.14] (inferred from 100% identity to ccs:CCNA_03562)

MetaCyc: 69% identical to ATP synthase subunit alpha, mitochondrial (Homo sapiens)

Predicted SEED Role

"ATP synthase alpha chain (EC 3.6.3.14)" in subsystem F0F1-type ATP synthase (EC 3.6.3.14)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.14

Use Curated BLAST to search for 3.6.3.14

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8H5I2 at UniProt or InterPro

Protein Sequence (510 amino acids)

>CCNA_03562 ATP synthase alpha chain (Caulobacter crescentus NA1000 Δfur)
MDIRAAEISAILKSQIANFGEEAAVSDVGQVLSVGDGIARIYGLDNVQAGEMLEFPKAGV
KGMALNLERDNVGAVIFGQDQEIKEGDEVRRLGEIVDVPVGRGLLGRVVNPLGEPIDGKG
PIQYTERRRVDVKAPGIIPRKSVHEPVQTGLKSIDTLIPVGRGQRELIIGDRQTGKTAVA
IDTILNQKAVNAGKDESAKLYCVYVAIGQKRSTVAQIVKTLEEHGALEYTTVVVASASEP
APLQYLAPFAGCAMGEWFRDNGLHGLIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVF
YLHSRLLERAAKLNEDNGSGSLTALPIIETQANDVSAYIPTNVISITDGQIFLETDLFYQ
GIRPAVNVGISVSRVGSSAQIKAMKQVAGPIKGELAQYREMAAFAKFGSDLDASTQKMLA
RGERLTELLKQPQYAPLSVEEQVCVIYAGTRGYLDGIPTSSVRRFEAEFLARLHSQHADL
LEGIRTKKALDKDLENTLKSALDSFSSTFA