Protein Info for CCNA_03320 in Caulobacter crescentus NA1000 Δfur

Annotation: biotin carboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1078 PF00289: Biotin_carb_N" amino acids 3 to 110 (108 residues), 142.1 bits, see alignment E=3.2e-45 PF02786: CPSase_L_D2" amino acids 115 to 322 (208 residues), 157.8 bits, see alignment E=9.9e-50 PF02785: Biotin_carb_C" amino acids 337 to 445 (109 residues), 111.3 bits, see alignment E=8.7e-36 PF00364: Biotin_lipoyl" amino acids 485 to 541 (57 residues), 47.9 bits, see alignment 3.4e-16 PF01039: Carboxyl_trans" amino acids 590 to 1064 (475 residues), 274.3 bits, see alignment E=6.9e-85 PF03255: ACCA" amino acids 895 to 975 (81 residues), 32.3 bits, see alignment 2.1e-11

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccr:CC_3214)

Predicted SEED Role

"Biotin carboxylase (EC 6.3.4.14)" (EC 6.3.4.14)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 6.3.4.14

Use Curated BLAST to search for 6.3.4.14

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CBA7 at UniProt or InterPro

Protein Sequence (1078 amino acids)

>CCNA_03320 biotin carboxylase (Caulobacter crescentus NA1000 Δfur)
MSLSRVLIANRGEIAVRIARTAAEAGLESVAIYAADDAQSPHVSAADHAVALPGAGARAY
LDIAAVVAAAKAQGCDALHPGYGFLSENPHLARACAEAGIVFIGPSPEHLTTFGDKAAAR
ALAAERGLPLIPGTGAITLEAARAFQAEHGAIMLKARAGGGGRGMRMVLDPGELDAAFAA
CEREALAAFGDGGLYAEKLIERARHIEVQIVGDGDQVLALGDRDCSLQRRNQKLVEIAPA
ALPDNLRAALAGWSERLCAGYRGLATVEFLVDADPHSPSGGEAFFIEVNPRLQVEHTVTE
EVTGLDLVRLQFDLAAGKRLGELELTNTPPPFGVAIQARINAETLTPEGQVRPSTGTLSA
WTPPGGPGVRVDAGVAAGLTIGAAYDSLLAKVIVRGRTPSEAASRLDRALTELKVAGVAT
TAPLVRAILAHPTAVTGEATTTFIAQHAETLAAEAQRLTPETTASVTRFEVLAGAEPVVA
PLAATVGAITIREGDLVRPGQALAVLEAMKMEHLVSASAGGRVVKIVVQGGATVAEGQPL
VFLEPAEVESALDGETVEQDLDALRPDLAEVVARHRHTLDEARPEAVAKRRKTGHRTARE
NIDDLVDPGSFLEYGALAIAAQKRRRSTEDLIANTPADGLITGIGTVNGALFPPDKARTA
ALAYDFTVLAGTQGAMNHRKSDRLMALIADQKLPVVWFAEGGGGRPGDTDTTAVAGLDVP
TFRSFAQLSGLVPKIAIVAGRCFAGNAAIAGLSEIIIATRDSNLGMGGPAMIEGGGLGVF
RPEEIGPSAHQWKNGVIDILADDEAHATRLAKQALSYFQGTLSTWTAPDQRRLRHAIPEN
RLRVYDVRGLINHLVDEGSFLELRGGFAAGMVTGLIRIEGRPMGLIANDPRHLGGAIDCE
GAEKAARFLQLCDAFALPVLSLCDTPGFMVGPDSEDAAAVRRVSRQFIAGAKLRSPLFTI
VTRKGYGLGAQAMAGGSFHSPAFIAAWPTGEFGGMGLEGAVKLGYRKELEAETDPVKQKA
LYDQLVARLYAAGKATSMAAALEIDAVIDPADTRRWVIGGLDAAAGVSRPWEVRVDSF