Protein Info for CCNA_03195 in Caulobacter crescentus NA1000 Δfur

Annotation: RNA polymerase sigma factor RpoH

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 298 TIGR02392: alternative sigma factor RpoH" amino acids 17 to 287 (271 residues), 371.8 bits, see alignment E=2.3e-115 PF00140: Sigma70_r1_2" amino acids 19 to 46 (28 residues), 33.2 bits, see alignment (E = 6.5e-12) TIGR02937: RNA polymerase sigma factor, sigma-70 family" amino acids 51 to 285 (235 residues), 114.9 bits, see alignment E=3e-37 PF04542: Sigma70_r2" amino acids 55 to 123 (69 residues), 63.3 bits, see alignment E=2.2e-21 PF04545: Sigma70_r4" amino acids 233 to 284 (52 residues), 61.2 bits, see alignment 8.2e-21

Best Hits

Swiss-Prot: 100% identical to RPOH_CAUVN: RNA polymerase sigma factor RpoH (rpoH) from Caulobacter vibrioides (strain NA1000 / CB15N)

KEGG orthology group: K03089, RNA polymerase sigma-32 factor (inferred from 100% identity to ccs:CCNA_03195)

Predicted SEED Role

"RNA polymerase sigma factor RpoH" in subsystem Heat shock dnaK gene cluster extended or Transcription initiation, bacterial sigma factors

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See B8H3C3 at UniProt or InterPro

Protein Sequence (298 amino acids)

>CCNA_03195 RNA polymerase sigma factor RpoH (Caulobacter crescentus NA1000 Δfur)
MSKMAVNSLSVMSPDGGLSRYLTEIRKFPMLSKDEEFMLAQRWKEHQDPQAAHKMVTSHL
RLVAKIAMGYRGYGLPIGEVISEGNVGLMQAVKKFEPEKGFRLATYAMWWIRASIQEYIL
RSWSLVKMGTTAAQKKLFFNLRKAKSQIAAFQEGDLHPDQVSQIATKLGVLDSEVISMNR
RLSGPDASLNAPLRADGESEWQDWLADEEQVSQETRVAEDEEKSLRMSLLEEAMVELTDR
ERHILTERRLKDDPTTLEELAAQYGVSRERVRQIEVRAFEKLQKTMREAAIAKNMVDA