Protein Info for CCNA_03162 in Caulobacter crescentus NA1000 Δfur

Annotation: bifunctional ornithine acetyltransferase/N-acetylglutamate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00120: glutamate N-acetyltransferase/amino-acid acetyltransferase
  • amino acids 87 to 481 (395 residues), 380.6 bits, E=4.1e-118
• PF01960: ArgJ
  • amino acids 94 to 481 (388 residues), 457 bits, E=2.2e-141

Best Hits

Swiss-Prot: 100% identical to ARGJ_CAUVC: Arginine biosynthesis bifunctional protein ArgJ (argJ) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K00620, glutamate N-acetyltransferase / amino-acid N-acetyltransferase [EC: 2.3.1.1 2.3.1.35] (inferred from 100% identity to ccs:CCNA_03162)

Predicted SEED Role

"Glutamate N-acetyltransferase (EC 2.3.1.35) / N-acetylglutamate synthase (EC 2.3.1.1)" in subsystem Arginine Biosynthesis extended (EC 2.3.1.1, EC 2.3.1.35)

MetaCyc Pathways

• L-arginine biosynthesis II (acetyl cycle) (10/10 steps found)
• L-arginine biosynthesis I (via L-ornithine) (9/9 steps found)
• L-arginine biosynthesis III (via N-acetyl-L-citrulline) (8/9 steps found)
• L-ornithine biosynthesis I (5/5 steps found)
• superpathway of arginine and polyamine biosynthesis (12/17 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid
• Urea cycle and metabolism of amino groups

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.3.1.1 or 2.3.1.35

Sequence Analysis Tools

See A0A0H3CE38 at UniProt or InterPro

Protein Sequence (481 amino acids)

>CCNA_03162 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase (Caulobacter crescentus NA1000 Δfur)
MPKTTKTPADNAAEPVATPAERAHGVIDAIVDPLTSALKRAGLRRAQKSAGESDQASATP
AKAATGAGKPGLAISPLAVPFPTIPPIAGVEIATGRAGFYKHEREDLLLMRFAEGTSAAG
VFTRHGVGSAPVDWCKRQLAATGGADVRALVVNAGCANSFTGKPGADAVRRVATAVGKRF
DCRQRDVMMASTGVIGVILDDSKITARLPEVESRLKADAWAEAGRAIMTTDTFPKGAYAT
AVIDGHEVKIAGIAKGSGMIAPDMATMLAFVATDAAIAPAALQTLVSLYTRTTFNCVTVD
GDRSTNDTLLLFATGQSGAPKIHRAGDKRLADFREKLEGVLLDLALQLVKDGEGATKFVK
ITVNGAESPASARKIARTIAESPLVKTAFAGEDANWGRIVMAVGRADEPVAREKISVKFG
DLYAARDGLISAEYDEAKMSAYVKNQAFEVSVDVGVGRGSATVWTCDLTKQYVAINGDYR
S