Protein Info for CCNA_02967 in Caulobacter crescentus NA1000 Δfur

Annotation: PAS-family sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 799 transmembrane" amino acids 37 to 60 (24 residues), see Phobius details amino acids 75 to 103 (29 residues), see Phobius details amino acids 116 to 137 (22 residues), see Phobius details PF08447: PAS_3" amino acids 178 to 263 (86 residues), 50.2 bits, see alignment E=1e-16 amino acids 306 to 389 (84 residues), 44.4 bits, see alignment E=6.4e-15 TIGR00229: PAS domain S-box protein" amino acids 278 to 403 (126 residues), 67.2 bits, see alignment E=7.3e-23 PF00989: PAS" amino acids 283 to 390 (108 residues), 32.8 bits, see alignment E=2.4e-11 PF08448: PAS_4" amino acids 289 to 397 (109 residues), 26.7 bits, see alignment E=2.3e-09 PF13426: PAS_9" amino acids 292 to 395 (104 residues), 21.1 bits, see alignment E=1.2e-07 PF00512: HisKA" amino acids 438 to 500 (63 residues), 30.5 bits, see alignment 1.2e-10 PF02518: HATPase_c" amino acids 546 to 660 (115 residues), 65.4 bits, see alignment E=2.5e-21 PF00072: Response_reg" amino acids 684 to 793 (110 residues), 56.4 bits, see alignment E=1.2e-18

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_02967)

Predicted SEED Role

"Sensory box sensor histidine kinase/response regulator (EC 2.7.3.-)" (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.3.-

Use Curated BLAST to search for 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CBZ2 at UniProt or InterPro

Protein Sequence (799 amino acids)

>CCNA_02967 PAS-family sensor histidine kinase (Caulobacter crescentus NA1000 Δfur)
MPGAGMEKKDNSIRAFDDQGRIHALISAWLIPPVPPPAWLCAIASIIGVAMAILMRVGLL
GLSSGVGATQPFFPAIMLVTLYAGWRWGMIPTLAGVVFSWWLWGGRHDEPLNSDELSSIV
IYLICGLMVAAVAEGLRGAMRGLAAARAQRANVEARLRVTQAAAGVGPWDYDLATGELYL
SPAARRNLGVPENADILLSDLPRFVHPDDRAMTEAVVFGALDGLTDYEVEYRLADTSQGE
RWVHGRGEVMRDDAGQPVRMIGLNFDVTNRRRAEAEVRESEARFRALADSAPAPMWVTRS
DGVREFVNNAYVAFVGLDYDSALTLDWRTRIFPEDLPRILKEQVAGETSRRPFSLEARYR
RADGEWRWLKSFSQPRYDPSGAFAGFIGMAFDTTEAKQAEAKLTGLNELLEERVTAALAE
RDAAQAALLQSQKLEAIGQLTGGVAHDFNNLLTVIIGALDVVERHPDDARRRERMIGAAL
AAAKRGEKLTQHLLAFARRQPLKPEICRVDGLIAESEGLLKRALGDAYTFHLRLGAGVRS
ARIDAGQFEAALLNLVVNARDATPPGGEVSIESRPVTLDRKEGDLEPGQYLRVAVRDTGT
GMDAATIARAVEPFFTTKPPGEGTGLGLSQVYGFARQSGGSVLIESTPGQGATVALLLPV
SAGDAASESLPRVDHIRAQTPSRVLLVEDDPQVAELVDAMLNDLGHSVVRAGGVDEALSR
LEQDDGIQLVLSDVIMPGGKSGVDLAEALAASRPGLPVVLCSGYTGGDQGRARAGGWPFI
SKPFSLETLAQALAQARPH