Protein Info for CCNA_02884 in Caulobacter crescentus NA1000 Δfur

Annotation: TetR-family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 255 PF00440: TetR_N" amino acids 66 to 112 (47 residues), 52.6 bits, see alignment 3e-18 PF08362: TetR_C_3" amino acids 113 to 254 (142 residues), 186 bits, see alignment E=3.5e-59

Best Hits

Swiss-Prot: 54% identical to RUTR_ECOL6: HTH-type transcriptional regulator RutR (rutR) from Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)

KEGG orthology group: K09017, TetR/AcrR family transcriptional regulator (inferred from 100% identity to ccs:CCNA_02884)

Predicted SEED Role

"Transcriptional regulator RutR of pyrimidine catabolism (TetR family)" in subsystem Pyrimidine utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CAY2 at UniProt or InterPro

Protein Sequence (255 amino acids)

>CCNA_02884 TetR-family transcriptional regulator (Caulobacter crescentus NA1000 Δfur)
MADPIAKTVKPPRGAAARPAAKGASGARKLVKAAQSVGEAGDGRAAGGARPPGPRERAGE
ARRAAILKAALAVFARLGPEGASVEAIAQAAGVSKPNLLYYYPSKDALYLAVLEQGLALW
LSPLGRFTEADDPAEAIAALIAAKLEMSRDHPEVSRLFALEMLRGAPLLKPVLSGPLKAV
FEAKCAVIAAWVAAGKLAPVDPPHLIFAIWALTQHYADFAVQVRALSGKSLSDRTFMDET
RAAVTALVLHGALPH