Protein Info for CCNA_02811 in Caulobacter crescentus NA1000 Δfur

Annotation: heavy metal translocating P-type ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 677 transmembrane" amino acids 43 to 61 (19 residues), see Phobius details amino acids 67 to 86 (20 residues), see Phobius details amino acids 98 to 115 (18 residues), see Phobius details amino acids 121 to 138 (18 residues), see Phobius details amino acids 283 to 302 (20 residues), see Phobius details amino acids 314 to 336 (23 residues), see Phobius details amino acids 628 to 646 (19 residues), see Phobius details amino acids 652 to 671 (20 residues), see Phobius details TIGR01525: heavy metal translocating P-type ATPase" amino acids 100 to 669 (570 residues), 571.2 bits, see alignment E=4.3e-175 TIGR01494: HAD ATPase, P-type, family IC" amino acids 123 to 399 (277 residues), 127 bits, see alignment E=1.1e-40 amino acids 464 to 648 (185 residues), 131.4 bits, see alignment E=5.1e-42 PF00122: E1-E2_ATPase" amino acids 150 to 341 (192 residues), 177.7 bits, see alignment E=1.7e-56 PF00702: Hydrolase" amino acids 361 to 580 (220 residues), 122 bits, see alignment E=4.2e-39

Best Hits

KEGG orthology group: K01534, Cd2+/Zn2+-exporting ATPase [EC: 3.6.3.3 3.6.3.5] (inferred from 100% identity to ccr:CC_2726)

Predicted SEED Role

No annotation

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.3

Use Curated BLAST to search for 3.6.3.3 or 3.6.3.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CA19 at UniProt or InterPro

Protein Sequence (677 amino acids)

>CCNA_02811 heavy metal translocating P-type ATPase (Caulobacter crescentus NA1000 Δfur)
MAAGIKPLQALHEPSPDHGPNTGQHSHEGDHARTLGGVLAKNAELVLATGSGAALAAGWL
LSLRAPGLAPLLCFLLAYGLGGVFTLKEAIENLRKRRLAIDSLMLVAAVGAAALGQWAEG
ALLLFLFSIGHALEHFAMGRARRAIEALAKLAPERASVRRGDTVVDVSIEDLEIGDIVLV
RPNARIACDGLVIVGQSSVDQAPVTGESVPVDKRPARDPALSFERAGAEHRVFAGTINGA
GALDIRVARKASETTLARVVRMVAEAEAQRSPTQQFTDRFERIFVPLVLLAVGLLMLAFL
VIEEPFNVSFYRAMAVLVAASPCALAISVPSAVLSGVARAGRGGVLIKGGGPLENLGALS
AMAFDKTGTLTQGKPRLTDVRPEQGVQEHDLLAVAVAVEALSDHPLAGAMVRDGLERLGS
RAPGRAEAARSLTGKGVWALVSGKAAIIGKPGLFDGKDAPTMTVSVQALAEDLEAQGRTV
VVVSHGERFLGVLGLMDTPRPAAKEVIQRLRRLGLKQIIMLSGDNQTVVSAVGRELGLDE
ARGGLMPEDKVAIIREMAARNGRVAMVGDGVNDAPAMANATVGVAMGAAGSDVALETADV
ALMADDLSHLPFAVGLSRQTSRIIKQNLWVSLGMVALLIPAALFGLQIGVAVVFHEGSTL
LVVANALRLLAYRDRTA