Protein Info for CCNA_02809 in Caulobacter crescentus NA1000 Δfur

Annotation: AcrB-family cation/multidrug efflux pump

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1080 transmembrane" amino acids 12 to 32 (21 residues), see Phobius details amino acids 374 to 402 (29 residues), see Phobius details amino acids 419 to 438 (20 residues), see Phobius details amino acids 473 to 493 (21 residues), see Phobius details amino acids 505 to 531 (27 residues), see Phobius details amino acids 562 to 583 (22 residues), see Phobius details amino acids 905 to 924 (20 residues), see Phobius details amino acids 931 to 950 (20 residues), see Phobius details amino acids 957 to 981 (25 residues), see Phobius details amino acids 1003 to 1022 (20 residues), see Phobius details amino acids 1034 to 1057 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1070 (1070 residues), 1536.5 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1058 (1053 residues), 966.5 bits, see alignment E=8.1e-295

Best Hits

Swiss-Prot: 62% identical to NCCA_ALCXX: Nickel-cobalt-cadmium resistance protein NccA (nccA) from Alcaligenes xylosoxydans xylosoxydans

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 56% identity to bml:BMA10229_0401)

MetaCyc: 54% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CBK5 at UniProt or InterPro

Protein Sequence (1080 amino acids)

>CCNA_02809 AcrB-family cation/multidrug efflux pump (Caulobacter crescentus NA1000 Δfur)
MIGRILDLSVRARWAVIAVVALVAALGVYNLIRLPIDAVPDITNKQVQINTVVPALAPAE
VEKLVTFPVETAMSGIPGLESTRSISRNGFSQVTIVFQEKTDLYFARQQVSERLTSVGKA
LPEGAQPAMGPISSGLGEVLMWTVAYDHPGGRGARVKDGAPGWQSDGAYLTITGERLTDT
TAQAAYLREVQDWIVRPQMRGVAGVAGVDSIGGYEKQFAVQPDPARMASYGVSFSQLAKA
LEAANIAVGANFMERGGEAYLVRADARVRNIDEIANATVATRAGMPIRVRDLATLKVGGG
LRTGAASENGEEVVVGTVLMLTGENSRAVAGASAERLKAIAKTLPPGVRVQITYDRSKLV
NATIKTVEKNLVEGALLVIAVLFVLLGNFRAALITALVIPLSMLMTAIGMNRLGVSGNLM
SLGALDFGLIVDGAVIIVENSLRRLAERQHQEGRLLTSSERLHETREAAREMIAPTVYGQ
AIILLVYAPLLTFTGVEGKTFSPMAITVMLALAAAFVLSLTFIPAMVALLIRGKVAEKEV
ALVRWAKVGYAPLLRKAVARPWPVIAAATGLFVVAMITFTFLGREFTPQLDEKDLAVQAL
RIPSTSLEQSLRMQRQIERTIAAFPEVEFVYSKTGTAEVASDPMPPNASDSFIILKAQDE
WPDSKQSKAQLVDRMERKLEGLTGNVYEFSQPIQMRFNELIAGVRGDVAIKVYGDDLAAM
TASADQIAGVLRGVRGAADVKVEQTSGFPTLDVSLDRDAIGRLGLTVEEVADTLAVAMGG
RASGLVFQGDRRFEVVVRLPEATRNDLDAIGALPVMLPHGASAGPRLSVPLRDVARFSFS
EGLNQVSRENGKRRVVVQANVRGNDLGSFVSEAQAKVSAQIELPAGSWVEWSGQFENLKA
AQSRLSLVVPLCFLLIFALLYMALGGFAPALAVFSAIPLALAGGVFGLALRGIPFSVSAA
VGFIALSGVAVLNGLVMMTAIRQRLAQGLALEQAIIAGAMERLRPVMMTGLVASLGFVPM
ALATETGAEVQRPLATVVIGGLITATALTLFVLPAICRFVLRQAPKATPEPAAPPQEQGA