Protein Info for CCNA_02806 in Caulobacter crescentus NA1000 Δfur

Annotation: nickel-cobalt-cadmium resistance protein NccC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 412 signal peptide" amino acids 1 to 35 (35 residues), see Phobius details PF02321: OEP" amino acids 33 to 214 (182 residues), 64.5 bits, see alignment E=5.6e-22 amino acids 240 to 405 (166 residues), 80.2 bits, see alignment E=9.2e-27

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_02806)

Predicted SEED Role

"Heavy metal RND efflux outer membrane protein, CzcC family" in subsystem Cobalt-zinc-cadmium resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CA14 at UniProt or InterPro

Protein Sequence (412 amino acids)

>CCNA_02806 nickel-cobalt-cadmium resistance protein NccC (Caulobacter crescentus NA1000 Δfur)
MPSSYAWPVAFGAALGFMSLGAPSGAAVAPVTLAQALQRAQAQSPLISSAQAALDAARGR
ARQAGFSPNPEAGLQSENIAGSGPYQGISNAETTFSLGQRLELGGKRRTRVATAQAEVET
AAVRAAIARADLTQEVKTRYALALEAKARVAVAQEAAERARDLARVAAALVEAGREPPLR
ALRARTASDEAEAAVLAAQTLALAARRALTSLWGDPDFEIELVEPLAAPTPQMAVDPNIS
LDVRLAQAERAAAEAAIERERAAGDPDLTIQAGVRRFEQTGDRALIVGFTAPIPIRDRNQ
GNVAAARADANAAQARERLALTGSIRAMRDAQASLKAAEARLEVLSSRTVPQAQQAVDLA
RQGFEAGKFSLLDVLDAQAALLASRNDLIAARLERALALAALERAAAQEDRS