Protein Info for CCNA_02479 in Caulobacter crescentus NA1000 Δfur
Annotation: aryl-alcohol dehydrogenase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 50% identical to XYLB_PSEPU: Aryl-alcohol dehydrogenase (xylB) from Pseudomonas putida
KEGG orthology group: K00055, aryl-alcohol dehydrogenase [EC: 1.1.1.90] (inferred from 100% identity to ccr:CC_2396)MetaCyc: 50% identical to benzyl alcohol dehydrogenase subunit (Pseudomonas putida mt-2)
Aryl-alcohol dehydrogenase. [EC: 1.1.1.90]; 1.1.1.90 [EC: 1.1.1.90]; 1.1.1.90 [EC: 1.1.1.90]; 1.1.1.90 [EC: 1.1.1.90]
Predicted SEED Role
"S-(hydroxymethyl)glutathione dehydrogenase (EC 1.1.1.284)" in subsystem Glutathione-dependent pathway of formaldehyde detoxification (EC 1.1.1.284)
MetaCyc Pathways
- formaldehyde oxidation II (glutathione-dependent) (3/3 steps found)
- 1,3-dimethylbenzene degradation to 3-methylbenzoate (2/3 steps found)
- 1,4-dimethylbenzene degradation to 4-methylbenzoate (2/3 steps found)
- 3-chlorotoluene degradation II (2/3 steps found)
- toluene degradation to benzoate (2/3 steps found)
- protein S-nitrosylation and denitrosylation (3/5 steps found)
- salicin biosynthesis (2/6 steps found)
- m-cresol degradation (1/5 steps found)
- superpathway of C1 compounds oxidation to CO2 (4/12 steps found)
- toluene degradation IV (aerobic) (via catechol) (4/13 steps found)
- salicortin biosynthesis (1/9 steps found)
- 2,5-xylenol and 3,5-xylenol degradation (3/13 steps found)
- superpathway of aerobic toluene degradation (12/30 steps found)
KEGG Metabolic Maps
- Biphenyl degradation
- Caprolactam degradation
- Methane metabolism
- Phenylalanine metabolism
- Toluene and xylene degradation
- Tyrosine metabolism
Isozymes
Compare fitness of predicted isozymes for: 1.1.1.284
Use Curated BLAST to search for 1.1.1.284 or 1.1.1.90
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0H3C967 at UniProt or InterPro
Protein Sequence (366 amino acids)
>CCNA_02479 aryl-alcohol dehydrogenase (Caulobacter crescentus NA1000 Δfur) MQVTAAVTRSPSGPFSLEALDIEPPRAGEILVRVVATGVCHTDMVMRDQHLPTPQPVVLG HEGAGVVEQVGPGVAKVAVGDHVVMTFNSCGRCPSCSDHAPTYCHEFFPRNFMGAREDGS SGLSKGSEVIHANIFGQSSFATYALCHERNAVKVDKTAPLERLGPLGCGVMTGAGAVMNA LKVPAGRSLVVFGAGAVGLSAVLAAKAIGAGPIIAIDINPERLALALELGADHALNGAEG GVVEKIQAITGTGAHFSIDTTANLKVMRQAVDCLGARGVCGLVGASKMGDELPLDAVSVM SGGKVVRGVVEGDADPDVFIPELIALHLAGRFPFDRLIQFYPLAEINQAVSDGETGRVIK PVVRMS