Protein Info for CCNA_02431 in Caulobacter crescentus NA1000 Δfur

Annotation: histidinol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 428 PF00815: Histidinol_dh" amino acids 26 to 424 (399 residues), 531.9 bits, see alignment E=6.1e-164 TIGR00069: histidinol dehydrogenase" amino acids 33 to 423 (391 residues), 502 bits, see alignment E=7.1e-155

Best Hits

Swiss-Prot: 100% identical to HISX_CAUVC: Histidinol dehydrogenase (hisD) from Caulobacter vibrioides (strain ATCC 19089 / CB15)

KEGG orthology group: K00013, histidinol dehydrogenase [EC: 1.1.1.23] (inferred from 100% identity to ccr:CC_2346)

Predicted SEED Role

"Histidinol dehydrogenase (EC 1.1.1.23)" in subsystem Histidine Biosynthesis (EC 1.1.1.23)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.23

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C921 at UniProt or InterPro

Protein Sequence (428 amino acids)

>CCNA_02431 histidinol dehydrogenase (Caulobacter crescentus NA1000 Δfur)
MRRFLFSDPDFQTAFKAFLDERRGSPADVDAAVAGVLEAVRTQGIEALLDYSRRFDKVDL
TAETIRVTAEEIEAGAAETPADVREAIAFAAARIRAYHSRQRPADQAWTDEAGVELGWRW
TPLEAVGVYVPGGRAAYPSTVLMNAVPAQVAGVDRIAMVTPPGKLQPAVLAAAKEAGVTE
IWRVGGAQAVAALAYGAGPIQPVDKIVGPGNAYVTAAKRRLYGVVGIDALAGPSEIVVVA
DNKNNPDWIAADLLSQAEHDPAAQSILITDDEAFAAAVEQAIAERLKTLATGEDAAASWR
DHGAVIIAPLDESPALVDAIAPEHVEFALDNPERLSDRVRHAGAIFLGRVTPEAIGDYVA
GSNHVLPTSRAARFQSGLSIYDFIKRTSIVKCDPASFAVLGPHTVALAKAEGLPAHALSA
SVRLPSGD