Protein Info for CCNA_02378 in Caulobacter crescentus NA1000 Δfur

Annotation: SIMPL family protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 248 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details PF04402: SIMPL" amino acids 44 to 244 (201 residues), 198.8 bits, see alignment E=6.4e-63

Best Hits

Swiss-Prot: 37% identical to BP26_BRUME: 26 kDa periplasmic immunogenic protein (bp26) from Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)

KEGG orthology group: K09807, hypothetical protein (inferred from 100% identity to ccs:CCNA_02378)

Predicted SEED Role

"Protein of unknown function DUF541"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CAI1 at UniProt or InterPro

Protein Sequence (248 amino acids)

>CCNA_02378 SIMPL family protein (Caulobacter crescentus NA1000 Δfur)
MTHTARRLPAIALPALLGGALLLGAAAPALAQSNDAAFKATTFNLSASGETLVAPDMATI
NLGVQTDATTAAEALKANGARMNQVMAALKKAGIADRDIQTSNLNLNAQYAYEQNQPPKL
TGYQASNQVTITVRDLAKLGAAVDATVGAGANTVNGISFGLANPQAAEDAARLEAVKALQ
AKAELYGRATGYKAVRLVNLSEGGGYSPVPPPMPVFAMAKREMSDATSIAAGELKVRIDV
SAVYEVSK