Protein Info for CCNA_02284 in Caulobacter crescentus NA1000 Δfur

Annotation: DNA-3-methyladenine glycosylase II

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 213 PF00730: HhH-GPD" amino acids 48 to 189 (142 residues), 66.3 bits, see alignment E=1.5e-22

Best Hits

KEGG orthology group: K01247, DNA-3-methyladenine glycosylase II [EC: 3.2.2.21] (inferred from 100% identity to ccr:CC_2201)

Predicted SEED Role

"HhH-GPD base excision DNA repair family protein; Probable 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase"

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.2.2.21

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3CBP4 at UniProt or InterPro

Protein Sequence (213 amino acids)

>CCNA_02284 DNA-3-methyladenine glycosylase II (Caulobacter crescentus NA1000 Δfur)
MFEPPSADAILAARRSLAAADPALATVEAVTPPFAWRVGLGGFPGLLKMIVQQQVSLASA
AAIWARVEAGLPEMTPEIVADHDEAYLRTLGLSQPKARYARAIAEAHLSGVCDFDALRAL
SDEEAIAALTAIKGVGRWTAEVFLMFTQGRLDLFPGGDVALQEAMRWVDRAETRPTEKQA
YARAELWRPYRGVAAHLLWACYGAVKRREIAPF