Protein Info for CCNA_01905 in Caulobacter crescentus NA1000 Δfur

Annotation: urea carboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1207 PF00289: Biotin_carb_N" amino acids 1 to 109 (109 residues), 150.1 bits, see alignment E=1.2e-47 TIGR02712: urea carboxylase" amino acids 2 to 1199 (1198 residues), 1816.1 bits, see alignment E=0 PF02786: CPSase_L_D2" amino acids 116 to 318 (203 residues), 209.8 bits, see alignment E=1.4e-65 PF07478: Dala_Dala_lig_C" amino acids 136 to 291 (156 residues), 37.3 bits, see alignment E=8.5e-13 PF02785: Biotin_carb_C" amino acids 336 to 440 (105 residues), 105.2 bits, see alignment E=7.9e-34 TIGR00724: biotin-dependent carboxylase uncharacterized domain" amino acids 448 to 765 (318 residues), 285.3 bits, see alignment E=5.3e-89 PF02626: CT_A_B" amino acids 472 to 743 (272 residues), 313.5 bits, see alignment E=5.5e-97 PF02682: CT_C_D" amino acids 798 to 1019 (222 residues), 121.2 bits, see alignment E=2e-38 PF00364: Biotin_lipoyl" amino acids 1125 to 1197 (73 residues), 50.7 bits, see alignment 5.2e-17

Best Hits

Predicted SEED Role

"Urea carboxylase (EC 6.3.4.6)" in subsystem Urea decomposition (EC 6.3.4.6)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.4.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C9E1 at UniProt or InterPro

Protein Sequence (1207 amino acids)

>CCNA_01905 urea carboxylase (Caulobacter crescentus NA1000 Δfur)
MFDKVLIANRGAIACRIIRTLRAMGVKSVAVFSDADAGSLHVSMADEAVRLGPAPAAESY
LRADLVLAAAQATGAQAIHPGYGFLSESAAFAQACEDAGVTFIGPSADNIRAFGLKHTAR
DLAQAHGVPLAPGTDLLTDPAAALAAAQRIGFPVILKATAGGGGIGMRVCESAEAVEEAF
AAVRRLATGNFSDGGVFLERYVHKARHIEVQVFGDGAGRVAALGERDCSLQRRNQKVVEE
TPAPGLPAATRTALLDAAVRLAKAANYRSAGTVEFLYDADRDDFFFLEVNTRLQVEHGVT
EQVTGVDLVEWMVRGAAGDFSFLDTPPPAPRGAAIQVRLYAEDPAQDYRPSAGVLTEVAF
PEGVRADGWVVDGTEVSAFYDPMLAKLIVIAEHRPAAVAALQAALDATRLAGIETNLDWL
RTVTRSQPFVSGEVSTRALETIAWAPDTIQVLSGGPATTVQDWPGRRGYWDVGVPPSGPM
DALAFRLGNRLLANPDDAAGLEITALGPTLKFNRPATLCLTGARFDARLDGVAVEPYTPF
DVRPGQTLKIGRVVEAGLRGYLLLRGGLDVPTYLGSRSTFTLGGFGGHAGRNLTAGDVLR
LLPAPEAPPGALDEPLRPALTKTWTIRVLPGPHGAPDFFTPADVAMIGGTDWKVHYNSNR
TGVRLVGPKPEWARRDGGEAGLHPSNIHDNAYAIGAIDFTGDMPIILGPDGPSLGGFVCP
FVIIEADLWKAGQLAPGDTVRFAVVDDPTAAAALETQEALIAQLGAAPPRPAPAVIDVEA
SPILRELPQDGHRPRVLYRRQGDQHLLVEYGPIVLDLELRLRIHALLLDLQAQALEGVID
LTPGIRSLQVHYDSRRLSQARLLDILVAAEDRLGGLDDFEIPSRVVHLPLSWKDPAIYQT
IDKYMQAVRDDAPWCPDNIEFIRRVNGLNGIDDVQKIVFDARYLVMGLGDVYLGAPVATP
VDPRHRLVTTKYNPARTWTPPNVVGIGGAYMCIYGMEGPGGYQLFGRTIQVWNTWRQTDA
FTDGKPWLLRFFDQIRFFPVSAEELVEWRRDFPLGRRAIRIEEETFRLSDYRRLLAENAE
SIAAFQSRRQAAFDAERADWEAKGEFARVEALSGVAEADDAVAAVEVPAGADLVEAPLGG
NVWKVLVEPGQAVEAGAVIAIIEAMKAECDVATPTAGVVSAVYAQPGQPIAAGAPVIAVT
PVAEAAA