Protein Info for CCNA_01730 in Caulobacter crescentus NA1000 Δfur

Annotation: amidophosphoribosyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01134: amidophosphoribosyltransferase
  • amino acids 28 to 474 (447 residues), 514.9 bits, E=1.2e-158
• PF13522: GATase_6
  • amino acids 92 to 221 (130 residues), 70.1 bits, E=2.9e-23
• PF13537: GATase_7
  • amino acids 110 to 225 (116 residues), 72 bits, E=6.7e-24
• PF00156: Pribosyltran
  • amino acids 298 to 398 (101 residues), 36 bits, E=6.7e-13

Best Hits

Swiss-Prot: 65% identical to PUR1_RHIEC: Amidophosphoribosyltransferase (purF) from Rhizobium etli (strain CFN 42 / ATCC 51251)

KEGG orthology group: K00764, amidophosphoribosyltransferase [EC: 2.4.2.14] (inferred from 100% identity to ccr:CC_1658)

Predicted SEED Role

"Amidophosphoribosyltransferase (EC 2.4.2.14)" in subsystem De Novo Purine Biosynthesis (EC 2.4.2.14)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis I (5/5 steps found)
• superpathway of 5-aminoimidazole ribonucleotide biosynthesis (5/6 steps found)
• 5-aminoimidazole ribonucleotide biosynthesis II (4/5 steps found)

KEGG Metabolic Maps

• Glutamate metabolism
• Purine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.4.2.14

Sequence Analysis Tools

See A0A0H3C8U0 at UniProt or InterPro

Protein Sequence (500 amino acids)

>CCNA_01730 amidophosphoribosyltransferase (Caulobacter crescentus NA1000 Δfur)
MTFLGQSTDRYSSSPWRDPEDDSLRLECGVFGVFGVRDAAAIAALGLHALQHRGQEACGI
AAFDGNRFHTERHMGHVGDAFTGADLVQRLPGNMAIGHTRYSTAGGSFIRNVQPMFADLE
TGGVAIAHNGNLTNFLTLRERLVQEGAIFQSTSDSEAILHLIARSRKAKIVDRFVDAISQ
IEGGYALVAITNKKMIGVRDPLGIRPLVLGDLDGKPVLASETCALDMIGARFVRDIEHGE
MVVIEETGITSTKPFQTAPARPCVFEYVYFARPDSVVNGRSVYGVRKRMGMNLAKETGVE
ADVVVPVPDSGVPAALGYAQQSGLPFEMGIIRNHYVGRTFIQPTQGVRELGVRMKHSPNR
AVLAGKRVVLIDDSIVRGTTSLKIVRMVREAGAKEVHLRSASPPIKWPDFYGIDMPEREQ
LLAANKSLEEMARFLEVDSLGFLSVDGLYDALEAGQRDPATPQFTDHYFTGDYPTRLTDR
EIAEGRNETNDKQLSLLVSA