Protein Info for CCNA_01689 in Caulobacter crescentus NA1000 Δfur

Annotation: inosine-5'-monophosphate dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01302: inosine-5'-monophosphate dehydrogenase
  • amino acids 6 to 453 (448 residues), 624.2 bits, E=6.7e-192
• PF00478: IMPDH
  • amino acids 6 to 472 (467 residues), 538.5 bits, E=1.3e-165
• PF00571: CBS
  • amino acids 91 to 138 (48 residues), 39.7 bits, 9.9e-14
  • amino acids 149 to 203 (55 residues), 35.4 bits, 2.2e-12
• PF03060: NMO
  • amino acids 240 to 371 (132 residues), 33.5 bits, E=6.2e-12
• PF01070: FMN_dh
  • amino acids 264 to 363 (100 residues), 26.7 bits, E=5.6e-10

Best Hits

Swiss-Prot: 67% identical to IMDH_RHITR: Inosine-5'-monophosphate dehydrogenase (guaB) from Rhizobium tropici

KEGG orthology group: K00088, IMP dehydrogenase [EC: 1.1.1.205] (inferred from 100% identity to ccs:CCNA_01689)

MetaCyc: 56% identical to inosine 5'-monophosphate dehydrogenase (Escherichia coli K-12 substr. MG1655)
IMP dehydrogenase. [EC: 1.1.1.205]

Predicted SEED Role

"Inosine-5'-monophosphate dehydrogenase (EC 1.1.1.205) / CBS domain" in subsystem Purine conversions (EC 1.1.1.205)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (42/46 steps found)
• superpathway of purine nucleotides de novo biosynthesis I (21/21 steps found)
• superpathway of purine nucleotides de novo biosynthesis II (23/26 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis I (6/6 steps found)
• purine nucleotides degradation I (plants) (10/12 steps found)
• adenosine nucleotides degradation I (7/8 steps found)
• superpathway of guanosine nucleotides de novo biosynthesis II (7/8 steps found)
• guanosine ribonucleotides de novo biosynthesis (4/4 steps found)
• inosine 5'-phosphate degradation (3/4 steps found)
• purine nucleotides degradation II (aerobic) (8/11 steps found)
• ureide biosynthesis (5/7 steps found)
• superpathway of purine nucleotide salvage (10/14 steps found)
• superpathway of purines degradation in plants (12/18 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Drug metabolism - other enzymes
• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.205

Use Curated BLAST to search for 1.1.1.205

Sequence Analysis Tools

See A0A0H3C768 at UniProt or InterPro

Protein Sequence (487 amino acids)

>CCNA_01689 inosine-5'-monophosphate dehydrogenase (Caulobacter crescentus NA1000 Δfur)
MEIREGLTFDDVLLEPAASDVMPTQVTTETRFTREISLNIPLVSAAMDTVTESRLAIAMA
QAGGMGVLHRNLSNEEQADQVREVKRYESGMVINPLTIHPDTTLAEIREIKARRKISGFP
VVERGSGKLVGILTNRDMRFEGDDKVPASQLMTRDNLITVSEGVDHREARELLRRHKIER
LIVVDEAYRAVGLITVKDIEKAQAHPLAAKDDKGRLLVGAASTVGDAGFERSMALVDAGV
DVVVIDTAHGHSSQVAAAVTRLKREANRVQIVAGNIATYDAARALIDAGADAVKVGIGPG
SICTTRIVAGVGVPQLTAIMEAVRAAKESNTPVIADGGIKYSGDLAKAIAAGASTAMMGS
MFAGTEEAPGEVFLYQGRSYKSYRGMGSVGAMARGSADRYFQKEVTDNFKLVPEGIEGQT
PFKGPISPVLHQLVGGLRAAMGYLGAPTIPELQKRARFVRITGAGLRESHVHDVMITREA
PNYPSAV