Protein Info for CCNA_01559 in Caulobacter crescentus NA1000 Δfur

Annotation: 2-deoxy-D-gluconate 3-dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 255 TIGR01832: 2-deoxy-D-gluconate 3-dehydrogenase" amino acids 5 to 255 (251 residues), 431.3 bits, see alignment E=5.5e-134 PF00106: adh_short" amino acids 10 to 205 (196 residues), 181.7 bits, see alignment E=1.7e-57 PF08659: KR" amino acids 12 to 132 (121 residues), 41.4 bits, see alignment E=2.2e-14 PF13561: adh_short_C2" amino acids 16 to 252 (237 residues), 194 bits, see alignment E=4.6e-61

Best Hits

Swiss-Prot: 64% identical to KDUD_DICD3: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase (kduD) from Dickeya dadantii (strain 3937)

KEGG orthology group: K00065, 2-deoxy-D-gluconate 3-dehydrogenase [EC: 1.1.1.125] (inferred from 100% identity to ccs:CCNA_01559)

MetaCyc: 64% identical to KduD (Dickeya dadantii 3937)
2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase. [EC: 1.1.1.127]

Predicted SEED Role

"2-deoxy-D-gluconate 3-dehydrogenase (EC 1.1.1.125)" in subsystem D-Galacturonate and D-Glucuronate Utilization (EC 1.1.1.125)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.125

Use Curated BLAST to search for 1.1.1.125 or 1.1.1.127

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C8A2 at UniProt or InterPro

Protein Sequence (255 amino acids)

>CCNA_01559 2-deoxy-D-gluconate 3-dehydrogenase (Caulobacter crescentus NA1000 Δfur)
MANPFSLEGKVALITGANTGIGQGIAIALAAAGADIAAAGRSAPTETQAAVEALGRKFLS
IKADFSSIEPVQRVVDETVAAFGKVDILVNNAGIIRRADSIEFSEADWDAVMDTNLKVVF
FLTQAFAKQALKQGFEGGQAKVINIASLLSFQGGIRVPSYTASKSGLAGLTKILANEWAT
KGINVNAIAPGYFDTNNTEALRADQDRNAAILARIPAGRWGRPEDIGGAAVFLASSASDY
VQGITLPVDGGWLAR