Protein Info for CCNA_01473 in Caulobacter crescentus NA1000 Δfur

Annotation: E1-E2 cation pump ATPase fixI

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 724 transmembrane" amino acids 108 to 132 (25 residues), see Phobius details amino acids 144 to 165 (22 residues), see Phobius details amino acids 180 to 199 (20 residues), see Phobius details amino acids 205 to 223 (19 residues), see Phobius details amino acids 358 to 380 (23 residues), see Phobius details amino acids 387 to 411 (25 residues), see Phobius details amino acids 673 to 691 (19 residues), see Phobius details amino acids 697 to 715 (19 residues), see Phobius details PF00403: HMA" amino acids 28 to 86 (59 residues), 44 bits, see alignment 3.6e-15 TIGR01511: copper-translocating P-type ATPase" amino acids 160 to 716 (557 residues), 479.6 bits, see alignment E=3e-147 TIGR01525: heavy metal translocating P-type ATPase" amino acids 179 to 716 (538 residues), 475.9 bits, see alignment E=4.3e-146 TIGR01512: cadmium-translocating P-type ATPase" amino acids 208 to 716 (509 residues), 342.7 bits, see alignment E=7.1e-106 TIGR01494: HAD ATPase, P-type, family IC" amino acids 213 to 702 (490 residues), 208.6 bits, see alignment E=2.6e-65 PF00122: E1-E2_ATPase" amino acids 241 to 419 (179 residues), 150.3 bits, see alignment E=6.6e-48 PF00702: Hydrolase" amino acids 437 to 628 (192 residues), 89.1 bits, see alignment E=7.8e-29

Best Hits

KEGG orthology group: K01533, Cu2+-exporting ATPase [EC: 3.6.3.4] (inferred from 100% identity to ccr:CC_1407)

Predicted SEED Role

"Type cbb3 cytochrome oxidase biogenesis protein CcoI; Copper-translocating P-type ATPase (EC 3.6.3.4)" (EC 3.6.3.4)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.3.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C6P0 at UniProt or InterPro

Protein Sequence (724 amino acids)

>CCNA_01473 E1-E2 cation pump ATPase fixI (Caulobacter crescentus NA1000 Δfur)
MSHSLALHRDLEAFVRRDDAGRGRFELLVRGARCAGCISKIEKAVRALPGVEAARLNLTT
GKLSVELAGKISDPGRVLETVEDLGYRACLFDPAEAEAAQDKEGKELALALGVAGFGAGN
VMMFTVPAWAGLFGQELTPATLTLMYWMAAIVATPCALFAGRPFFRSAWASLRRGKANMD
VPISIGVILTLIVSFSETLLGGKHAYFDAAVTLLFLLLIGRYLDHRLRAGARSAARDLLA
LQAPVARRLTDGVEQGVPVADIRVGDLLAVAPGERIPVDGLVEQGASELDNALITGETAL
APVAAGARLHAGALNLSGRLVMRASARSEDSTLAAIARLMEAGAQARSTYVRLADKAAAL
YVPVVHTAAALTFVGGWALGLGPREALLRAAAVLIVTCPCALGLAVPAVQIAASSRLFRR
GVLVKSGAALERLAEADHVVFDKTGVLTQGRPALIDAPAHLVAQAAPLARASRHPLARAL
AAEAGAGPVAQDCVETAGQGVEGVIDGRRARLGRAAFVGVQAGDVRETELWFGFENNVKI
RFAFEDRPRADARDTITKLRALGLSVEILSGDVEGPVRDVAREVGVSDWRAGLTPVEKAA
AIDALKAQGRKVLMVGDGLNDAAALSKAHASMAPGAAVDAAQNAADLVFTGDELAAVVES
IETAREARRRALENFGFSALYNLVATPAAMFGLVNPFVAALAMSGSSIVVLLNAARPRLR
SFNR