Protein Info for CCNA_01341 in Caulobacter crescentus NA1000 Δfur

Annotation: DegP/HtrA-family serine protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 472 signal peptide" amino acids 1 to 30 (30 residues), see Phobius details TIGR02037: peptidase Do" amino acids 51 to 470 (420 residues), 462.6 bits, see alignment E=6.7e-143 PF00089: Trypsin" amino acids 93 to 258 (166 residues), 58.4 bits, see alignment E=2.8e-19 PF13365: Trypsin_2" amino acids 99 to 235 (137 residues), 112.5 bits, see alignment E=9.2e-36 PF13180: PDZ_2" amino acids 277 to 364 (88 residues), 51.7 bits, see alignment E=2.6e-17 PF00595: PDZ" amino acids 285 to 332 (48 residues), 35.7 bits, see alignment 2.7e-12 PF17820: PDZ_6" amino acids 302 to 355 (54 residues), 41.5 bits, see alignment 2.8e-14

Best Hits

KEGG orthology group: None (inferred from 100% identity to ccs:CCNA_01341)

Predicted SEED Role

"Serine protease precursor MucD/AlgY associated with sigma factor RpoE" in subsystem Transcription initiation, bacterial sigma factors

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0H3C696 at UniProt or InterPro

Protein Sequence (472 amino acids)

>CCNA_01341 DegP/HtrA-family serine protease (Caulobacter crescentus NA1000 Δfur)
MTNMRKLRALLPVFVLLTACSNPAGPSNAQSIPDMPQPTRQVPADAASMKQSFSPVVKKA
APAVVNVASRRLVQRRVDPFWDFFMGGGQGGSQVQSSLGSGAIVRADGVIITNHHNINGM
SDITIQLADRREFPAVVLLDDPRADLAVLKIDTKGEKLPVMAIDDQEQLEVGDLVLAMGN
PFGVGQTVTNGIVSALARTDVGAADFGSYIQTDAAINPGNSGGPLVDMDGDLVGINTFII
SRSGSSSGVGFAIPARVVRQVVNAALGGGHSIVRPWLGVKGQAVTGDIAKSLGMTAPRGV
LVAQIYPGSSAERAGLKEGDVILSIDGQPVNDEGGGAFAIGTHKVGDRVPMQIRRGDREL
TITVRADAAPETPARDERTLSGNNPFNGATVMNLSPAVAQDLGVDPFAGRGALVTKIGPG
YAGNWMRPGDFVRSVNGRQINTVADLASAIAGRSGRWSVTIERGGQLIQAQF